Inhibitors of the LFA-1/ICAM-1 interaction and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S537000

Reexamination Certificate

active

07943660

ABSTRACT:
The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.

REFERENCES:
patent: 5110797 (1992-05-01), Ienaga et al.
patent: 1220852 (2002-07-01), None
patent: 2216712 (2004-10-01), None
Trotter, Nicolas S. et al, “Synthesis and neuroprotective activity of analogues of glyycyl-L-prolyl-L-glutamic acid (GPE) modified at the a-carboxylic acid,” Bioorganic & Medicinal Chemistry 13 (2005), pp. 501-517, published online Oct. 28, 2004.
Accession No. 1989: 497740 HCAPLUS abstract of Ienaga, et al, JP 01052744 A, published 1989.
Trotter, Nicholas S. et al., Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-glutamic acid (GPE) modified at the alfa-carboxylic acid, Bioorganic & Medicinial Chemistry, vol. 13, 2005, pp. 501-517.
Springer T.A., Folding of the N-Terminal, Ligand-binding region of integrin alfa-subunits into a beta propeller domain, Prov Natl. Acad. Sci. USA, vol. 94, pp. 65-72, Jan. 1997.
Lee, Jie-Oh, Crystal Structure of the A Domain from the alfa subunit of Integrin CR3 (CD11b/CD18), Cell, vol. 80, pp. 631-638, Feb. 1995.
Vidal-Vanaclocha, Fernando et al., Interleukin-1 Receptor Blockade Reduces the Number and Size of Murine B16 Melanoma Hepatic Metastases, Cancer Research 54, pp. 2667-2672, May 1994.
Shimoaka, M et al., Structures of the Alfa-L I Domain and its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation, Cell vol. 112 pp. 99-111, Jan. 2003.

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