Inhibitors of the inositol polyphosphate 5-phosphate SHIP2...

Details Inhibitors of the inositol polyphosphate 5-phosphate SHIP2... Inhibitors of the inositol polyphosphate 5-phosphate SHIP2...

2005-08-30

2005-08-30

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C536S023740, C424S094500

Reexamination Certificate

active

06936452

ABSTRACT:
The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical composition comprising said inhibitor and an adequate pharmaceutically acceptable carrier or diluent and to a non-human knock-out mammal comprising homozygously or heterozygously a partial or total deletion in its genome of the inositol polyphoshate 5-phosphatase SHIP2 nucleotide sequence.

REFERENCES:
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patent: 05 194580 (1993-08-01), None
patent: WO 97/12039 (1997-04-01), None
patent: WO 97/22716 (1997-06-01), None
patent: WO 98/11901 (1998-03-01), None
Pesesse, et al. (1997). “Identification of a Second SH2-Domain-Containing Protein Closely Related to the Phosphatidylinositol Polyphosphate 5-Phosphatase SHIP,”Biochemical and BioPhysical Research Communications239:697-700.
Presesse, et al. (1998). “The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity,”FEBS Letters437:301-303.
Schurmans, et al. (1999). “The Mouse SHIP2 (Inppll) Gene: Complementary DNA, Genomic Structure, Promotor Analysis, and Gene Expression in the Embryo and Adult Mouse,”Genomics62:260-271.
Sasaoka, et al. (1999). “Molecular Cloning and Characterization of Rat SHIP2 in the Regulation of Insulin Action,”Diabetes48(Supp. 1):A60.

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