Inhibitors of the ICE/ced-3 family of cysteine proteases

Details Inhibitors of the ICE/ced-3 family of cysteine proteases Inhibitors of the ICE/ced-3 family of cysteine proteases

2005-11-29

2005-11-29

Lukton, David (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S331000, C514S018700, C562S561000, C562S563000

Reexamination Certificate

active

06969703

ABSTRACT:
This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure:wherein A, B, X, R, R1, R2, n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

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