Inhibitors of the GPIb-vWF interaction, their preparation...

Details Inhibitors of the GPIb-vWF interaction, their preparation... Inhibitors of the GPIb-vWF interaction, their preparation...

2007-04-02

2010-06-29

Kosack, Joseph R (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S313000, C514S339000, C514S367000, C514S394000, C544S405000, C546S159000, C546S268100, C548S159000, C548S304700

Reexamination Certificate

active

07745443

ABSTRACT:
The present invention relates to compounds of the formula I,in which R1, R2, A, B, D, E, n, m or o have the meanings indicated below.The compounds of the formula I are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb). They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of atherothrombotic diseases.

REFERENCES:
patent: 5919776 (1999-07-01), Hagmann et al.
patent: 0 614 664 (1994-09-01), None
patent: 1 074 564 (2001-02-01), None
patent: WO 98/27815 (1998-07-01), None
patent: WO 99/48492 (1999-09-01), None
Kageyama et al. “Anti-human vWF Monoclonal Antibody, AJvW-2 Fab, Inhibits Repetitive Coronary Artery Thrombosis without Bleeding Time Prolongation in Dogs” Thrombosis Research, 2001, vol. 101, pp. 395-404.
Bundgaard, “Novel Chemical Approaches in Prodrug Design,”Drugs of the Future16:443-458 (1991).
Fleisher et al., “Improved Oral Drug Delivery: Solubility Limitations Overcome by the Use of Prodrugs,”Advanced Drug Delivery Reviews19:115-130 (1996).
Lanza et al., “Substituted 4,6,-Diaminoquinolines as Inhibitors of C5a Receptor Binding,”M. Med. Chem. 35:252-258 (1992).
Kageyama et al., “Anti-Human vWF Monoclonal Antibody, AjvW-2 Fab, Inhibits Repetitive Coronary Artery Thromobosis Without Bleeding Time Prolongation in Dogs,”Thrombosis Research101:395-404 (2001).
Raynes et al., “Novel Bisquinoline Antimalarials,”Biochemical Pharmacology551-559 (1996).
Trebst, A., “Measurement of Hill Reactions and Photoreduction,”Meth Enzymol. 24:146-165 (1972).

Affiliated with

Also associated with

Rating

Inhibitors of the GPIb-vWF interaction, their preparation... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of the GPIb-vWF interaction, their preparation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of the GPIb-vWF interaction, their preparation... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4216688