Inhibitors of the advanced glycosylation of proteins and methods

Details Inhibitors of the advanced glycosylation of proteins and methods Inhibitors of the advanced glycosylation of proteins and methods

1991-03-25

1993-06-08

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514183, 514218, 514256, 514450, 514452, 424 49, A61K 3133, A61K 3155, A61K 31505, A61K 31335, A61K 3112, A61K 716

Patent

active

052180018

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins resulting from their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
patent: 3957967 (1976-05-01), L'Orange
Bonesvoll, Arc. Oral Biol., 22, pp. 273-279 (1977), "Influence of Ionic Strength, Calcium, Sodium Dodecyl Sulphate and Urea on the Retention of Chlorohexidine i the Human Mouth After Mouth Rinses."
Moeller et al., Chem. Abs., 87 (20): 157007b, (1977), "Use of Amides of Multibasic Aliphatic Carboxylic Acids as Skin Moisturizers."

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