Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1990-04-03
1992-12-29
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514563, 514626, 514616, 424 54, A61K 31195, A61K 3116, A61K 722
Patent
active
051751925
ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylatin. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
REFERENCES:
patent: 3957967 (1976-05-01), L'Orange
Bonesvoll, Archs. Oral Biol., 22 (1977) pp. 273-279.
CA 87(20):157007b, Moeller et al., 1977.
Cerami Anthony
Ulrich Peter C.
Jordan Kimberly R.
The Rockefeller University
Waddell Frederick E.
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