Inhibitors of tace

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S541000

Reexamination Certificate

active

07919520

ABSTRACT:
The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.

REFERENCES:
patent: 6313123 (2001-11-01), Levin et al.
patent: 7485664 (2009-02-01), Bandarage et al.
patent: 96/04242 (1996-02-01), None
patent: 00/44709 (2000-08-01), None
M. L. Moss, et al., Drug Discovery Today, 6, 417-426 (2001), esp. p. 417.
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Ohta et al. “Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis” Journal of Rheumatology, 2001, vol. 28, pp. 1756-1763.
Levin et al., “Acetylenic TACE Inhibitors Part 1. SAR of the Acyclic Sulfonamide Hydroxamates”, Bioorganic Medicinal Chemistry Letters, vol. 13, No. 16, pp. 2799-2803, 2003.
Office Action dated Feb. 15, 2007, in U.S. Appl. No. 10/741,164.
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Office Action dated Apr. 13, 2007, in U.S. Appl. No. 10/741,164.
Rao et al., “Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides”, Bioorganic Medicinal Chemistry Letters, vol. 17, pp. 2250-2253, (2007).
Bandarage, et al., “Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones”, Bioorganic Medicinal Chemistry Letters, vol. 18, pp. 44-48, (2008).

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