Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-25
2007-09-25
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S079000, C546S085000, C546S112000, C548S134000, C548S146000, C548S182000, C548S225000, C548S250000, C548S262200, C548S452000, C548S465000, C514S292000, C514S299000
Reexamination Certificate
active
10412600
ABSTRACT:
The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
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Han, Wei et al., “α-Ketoamides, α-Ketoesters and α-Diketones as HCV NS3 Protease Inhibitors,” Bioorganic & Medicinal Chemistry Letters, 2000, vol. 10, No. 8, pp. 711-713.
Cottrell Kevin M.
Courtney Lawrence F.
Farmer Luc J.
Murcko Mark A.
Perni Robert B.
Dixon Lisa A.
Kelly Susan C.
Shameem Golam M. M.
Vertex Pharmaceuticals Incorporated
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