Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-01-23
1998-12-08
Jarms, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514318, 514330, 514 12, A61K 31445, A61K 3818
Patent
active
058469818
ABSTRACT:
This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
REFERENCES:
patent: 4310461 (1982-01-01), Krapcho et al.
patent: 4390695 (1983-06-01), Krapcho et al.
patent: 4531964 (1985-07-01), Shimano et al.
patent: 4578474 (1986-03-01), Krapcho et al.
patent: 4593102 (1986-06-01), Shanklin, Jr.
patent: 5414083 (1995-05-01), Hackl et al.
patent: 5504197 (1996-04-01), Schubert et al.
patent: 5516797 (1996-05-01), Armistead et al.
patent: 5543423 (1996-08-01), Zelle et al.
Lyons et al, Chemical Abstracts, vol. 120, No. 25, abstract No. 315423r, p. 48, 1994.
Sharkey et al, Chemical Abstracts, vol. 121, No. 19, abstract No. 221398e, 1994.
Kelly et al, Chemical Abstracts, vol. 122, No. 10, abstract No. 114965m, p. 659, 1995.
Dumont, Francis J. et al., "The Immunosuppressive and Toxic Effects of FK-506 are Mechanistically Related: Pharmacology of a Novel Antagonist of FK-506 and Rapamycin," J. Exp. Med., 1992, 176, 751-760.
Schreiber, Stuart L., "Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands," Science, 1991, 251, 282-287.
Harding, M.W., et al. "A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase," Nature Lett., 1989, 341, 758-60.
Ponticelli, Claudio, "Treatment of the Nephrotic Syndrome with Cyclosporin A," J. of Autoimmunity, 1992, 5, 315-24.
Tindall, Richard S.A., "Immunointervention with Cyclosporin A in Autoimmune Neurological Disorders," J. of Autoimmunity, 1992, 5, 301-13.
Tugwell, Peter, "Cyclosporin in the Treatment of Rheumatoid Arthritis," J. of Autoimmunity, 1992, 5, 231-40.
Fry, Lionel, "Psoriasis: Immunopathology and Long-term treatment with Cyclosporin," J. of Autoimmunity, 1992, 5, 277-83.
Feutren, Gilles, "The Optimal use of Cyclosporin A in Autoimmune Diseases," J. of Autoimmunity, 1992, 5, 183-95.
Munoz, Benito et al., ".alpha.-Ketoamide Phe-Pro isostere as a new core structure for the inhbition of HIV protease," Bioorg. Med. Chem., 1994, 2(10), 1085-90.
Kaczmar, et al., Makromol. Chem., 1976, 177, 1981-9.
Steiner, Joseph P. et al., "High brain densities of the immunophilin FKBP colocalized with calcineurin," Nature Lett., 1992, 358, 584-7.
Dawson, Ted M. et al., "Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity," Proc. Natl. Acad. Sci. USA, 1993, 90, 9808-12.
Blaschke et al., Chemical Abstracts, 1974, 85, 78405k.
Caufield, Craig E. and Musser, John H., Annual Reports in Medicinal Chemistry, Johns (Ed.), Academic Press, Inc., Chapter 21, 195-204, 1989.
Effenberger F. et al., "Diastereoselective addition of benzenesulfenyl chloride to 1-acryloylproline esters," Chemical Abstracts, 1989, 10, 778-9.
Nakatsuta, M. et al. "Total Synthesis of FK506 and an FKBP Probe Reagent, (C.sub.8, C.sub.9 -.sup.13 C.sub.2) -FK-506," J. Am. Chem. Soc., 1990, 112 (14), 5583-90.
Dawson, T.M. et al., "The immunophilins, FK506 Binding Protein and Cyclophilin, are Discretely Localized in the Brain: Relationship to Calcineurin," Neuroscience, 1994, 62(2), 569-80.
Cameron, Andrew et al., "Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux," Proc. Natl. Acad. Sci. USA, 1995, 92, 1784-88.
Steiner, J.P. et al., "Nonimmunosuppressive Ligands for Neuroimmunophilins Promote Nerve Extension In Vitro and In Vivo," Society for Neuroscience Abstracts, 1996, 22, 297.13.
Lyons, W. Ernest et al., "Neuronal Regeneration Enhances the Expression of the Immunophilin FKBP-12," The Journal of Neuroscience, 1995, 15, 2985-94.
Hayward, C.M., et al., "An application of the Suarez reaction to the regiospecific of the C.sub.28 -C.sub.42 segment of rapamycin," 1993, 3989-92.
Hovarth, R. et al., "An application of the Evans-Prasad 1,3-Syn diol synthesis to a stereospecific synthesis of the C.sub.10 -C.sub.27 segment of rapamycin," Tetrahedron Lett., 1993, 34(25), 3993-3996.
Whitesell, J.K. et al., "Asymmetric Induction. Reduction, Nucleophilic Addition to, Ene Reactions of Chiral .alpha.-Ketoesters," J. Chem. Soc., Chem. Commun., 1983, 802.
Ando, Tako et al., "Formation of Crossed Phenzine from the reaction between Tetra-p-anisyl-and Tetra-p-tolyl-hydrazines in Liquid Sulphur Dioxide," Chem. Comm., S. Chem. Comm., 1975, 989.
Kino, Toru et al., "FK-506, A novel immunosuppressant isolated from A Streptomyces," J. of Antibiotics, 1987, 40(9), 1249-55.
Schreiber, Chemical Abstract, vol. 123:275997, 1995.
Rinehart, Chemical Abstracts, vol. 121:887, 1994.
Takeuchi, Checmical Abstract, vol. 122:131140, 1994.
Thaisrivongs, Chemical Abstract, vol. 117:112083, 1992.
Yamada, Chemical Abstract, vol. 117:212981, 1992.
Someno, Chemical Abstract, vol. 116:236174, 1992.
Schreiber, Chemical Abstract, vol. 116:34554, 1991.
Rinehart, Chemical Abstract, vol. 115:248086, 1991.
Baader, Chemical Abstract, vol. 116.129617, 1991.
Prasit, Chemical Abstract, vol. 115:207870, 1991.
Askin, Chemical Abstract, vol. 114:228633, 1991.
Jones, Chemical Abstract, vol. 114:81436, 1990.
Takeuchi, Chemical Abstract, vol. 115:90647, 1990.
Dreyer, Chemical Abstract, vol. 113:153045, 1990.
Bieringer, Chemical Abstract, vol. 113:226420, 1990.
Askin, Chemical Abstract, vol. 114:23615, 1990.
Goulet, Chemical Abstract, vol. 114:81347, 1990.
Jones, Chemical Abstract, vol. 112:235036, 1990.
Jones, Chemical Abstract, vol. 113:23463, 1990.
Rao, Chemical Abstract, vol. 113:191007, 1990.
Waldmann, Chemical Abstract, vol. 114:82457, 1990.
Finberg, Chemical Abstract, vol. 113:184256, 1990.
Gold, Chemical Abstract, vol. 111:195414, 1989.
Gold, Chemical Abstract, vol. 111:97735, 1989.
Matsuo, Chemical Abstract, vol. 112:158977, 1989.
Goodfellow, Chemical Abstract, vol. 111:93084, 1989.
Wasserman, Chemical Abstract, vol. 112:35516, 1989.
Wasserman, Chemical Abstract, vol. 111:57366, 1989.
Askin, Chemical Abstract, vol. 111:232396, 1989.
Faelth, Chemical Abstract, vol. 112:97901, 1989.
Boulmedais, Chemical Abstract, vol. 112:44174, 1989.
Coleman, Chemical Abstract, vol. 112:7219, 1989.
Egbertson, Chemical Abstract, vol. 110:57371, 1989.
De Luca, Chemical Abstract, vol. 111:23387, 1988.
Arzeno, Chemical Abstract, vol. 110:8697, 1988.
Williams, Chemical Abstract, vol. 109:170092, 1988.
Kocienski, Chemical Abstract, vol. 110:212441, 1988.
Tanaka, Chemical Abstract, vol. 107:175741, 1987.
Soai, Chemical Abstract, vol. 108:38323, 1987.
Munegumi, Chemical Abstract, vol. 107:218023, 1987.
Gavras, Chemical Abstract, vol. 105:6828, 1986.
Nestor, Chemical Abstract, vol. 106:214389, 1986.
Gante, Chemical Abstract, vol. 107:97131, 1986.
Soai, Chemical Abstract, vol. 105:134309, 1986.
Soai, Chemical Abstract, vol. 107:197713, 1986.
Soai, Chemical Abstract, vol. 103:70915, 1985.
Soai, Chemical Abstract, vol. 102:78344, 1984.
Harris, Chemical Abstract, vol. 99:88574, 1983.
Smith, Chemical Abstract, vol. 100:175294, 1983.
Ryan, Chemical Abstract, vol. 100:103897, 1983.
Soai, Chemical Abstract, vol. 99:105651, 1983.
Neustadt, Chemical Abstract, vol. 97:216730, 1982.
Ryan, Chemical Abstract, vol. 97:163506, 1982.
Colombo, Chemical Abstract, vol. 98:161133, 1982.
Soai, Chemical Abstract, vol. 98:88478, 1982.
Patchett, Chemical Abstract, vol. 95:25634, 1980.
Bender, Chemical Abstract, vol. 89:128811, 1978.
Steglich, Chemical Abstract, vol. 8:214864, 1978.
Cushman, Chemical Abstract, vol. 88:18091, 1977.
Steglich, Chemical Abstract, vol. 85:108966, 1976.
Bycroft, Chemical Abstract, vol. 84:106021, 1975.
Marshall, Chemical Abstract, vol. 83:178991, 1975.
Haeusler, Chemical Abstract, vol. 80:108833, 1974.
Hearn, Chemical Abstract, vol. 68:22217, 1967.
Burbaum, Chemical Abstract, vol. 123:170197, 1995.
Burbaum, Chemical Abstract, vol. 121:109686, 1994.
Armistead, Chemical Abstract, vol. 121:170549, 1994.
Armistead, Chemical Abstract, vol. 117:131071, 1992.
Holt, Chemical Abstract, vol. 125:86501, 1996.
Smith, C
Dawson Ted
Hamilton Gregory S.
Snyder Solomon
Steiner Joseph P.
GPI NIL Holdings Inc.
Jarms William R. A.
Johns Hopkins University School of Medicine
Juneau Todd L.
Nath Gary M.
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