Inhibitors of RNase P proteins as antibacterial compounds

Details Inhibitors of RNase P proteins as antibacterial compounds Inhibitors of RNase P proteins as antibacterial compounds

2006-02-21

2006-02-21

Kumar, Shailendra (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S616000, C514S469000, C514S367000, C514S467000, C514S468000, C514S157000

Reexamination Certificate

active

07001924

ABSTRACT:
The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazones, guanylhydrazone mimetics, and benzothiazolium compounds. Exemplary compounds are compounds of formula I:in-line-formulae description="In-line Formulae" end="lead"?Y—(NR′)k—U1—(NR″)I—A—(NR1)m—U2—(NR2)n—Z  Iin-line-formulae description="In-line Formulae" end="tail"?with substituents as described herein.

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