Inhibitors of retroviral reverse transcriptase

Details Inhibitors of retroviral reverse transcriptase Inhibitors of retroviral reverse transcriptase

2009-05-22

2011-10-04

Angell, J. E. (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100

Reexamination Certificate

active

08030475

ABSTRACT:
Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect is largely independent of aptamer sequence provided that the aptamer has the specified structure.

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