Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1996-06-25
2000-02-01
Brusca, John S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 6, 4352521, 536 237, 536 241, C12Q 100, C12Q 168, C12N 138, C12N 1531
Patent
active
060201215
ABSTRACT:
Methods are provided for screening for potential inhibitors of bacterial, or other microbial, global pathogenesis gene regulators and other gene regulators. Methods are also provided for treating microbial (e.g., bacterial) infections using such inhibitors. Also included are pharmaceutical compositions containing such inhibitors. The screening methods involve detecting whether the activity of a global pathogenesis gene regulator is altered in the presence of a test compound.
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Bao Ying
Boggs Amy
Contag Pamela R.
Federspiel Nancy A.
Hebert Alan
Brusca John S.
Microcide Pharmaceuticals, Inc.
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