Inhibitors of proteins that bind phosphorylated molecules

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S236800, C514S256000, C514S342000, C544S134000, C544S335000, C546S271100

Reexamination Certificate

active

07141596

ABSTRACT:
The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that are connected directly or indirectly to the activity of the target protein.

REFERENCES:
patent: 4428956 (1984-01-01), Cragoe, Jr. et al.
patent: 5276049 (1994-01-01), Himmelsbach et al.
patent: 5478942 (1995-12-01), Himmelsbach et al.
patent: 5650424 (1997-07-01), Himmelsbach et al.
patent: 5789374 (1998-08-01), Sprecker et al.
patent: 5798374 (1998-08-01), Tang et al.
patent: 5852192 (1998-12-01), Himmelsbach et al.
patent: 6001867 (1999-12-01), Wrobel et al.
patent: 6057316 (2000-05-01), Wrobel et al.
patent: 6110963 (2000-08-01), Malamas
patent: 6166069 (2000-12-01), Malamas et al.
patent: 6310081 (2001-10-01), Malamas et al.
patent: 6479493 (2002-11-01), Whitehead et al.
patent: 2002/0086853 (2002-07-01), Cherney et al.
patent: 2003/0060419 (2003-03-01), Hu et al.
patent: 2004/0167188 (2004-08-01), Xin et al.
patent: WO 97/40017 (1997-10-01), None
patent: WO 98/27065 (1998-06-01), None
patent: WO 98/27092 (1998-06-01), None
patent: WO 98/53814 (1998-12-01), None
patent: WO 98/56376 (1998-12-01), None
patent: WO 99/11606 (1999-03-01), None
patent: WO 99/58514 (1999-11-01), None
patent: WO 99/58518 (1999-11-01), None
patent: WO 99/58519 (1999-11-01), None
patent: WO 99/58521 (1999-11-01), None
patent: WO 99/58522 (1999-11-01), None
patent: WO 99/61410 (1999-12-01), None
patent: WO 00/17211 (2000-03-01), None
patent: WO 00/53583 (2000-09-01), None
patent: WO 00/69899 (2000-11-01), None
patent: WO 01/16097 (2001-03-01), None
patent: WO 01/16122 (2001-03-01), None
patent: WO 01/16123 (2001-03-01), None
patent: WO 01/17516 (2001-03-01), None
patent: WO 01/19830 (2001-03-01), None
patent: WO 01/19831 (2001-03-01), None
patent: WO 01/46203 (2001-06-01), None
patent: WO 01/46204 (2001-06-01), None
patent: WO 01/46205 (2001-06-01), None
patent: WO 01/46206 (2001-06-01), None
patent: WO 01/70753 (2001-09-01), None
patent: WO 01/70754 (2001-09-01), None
patent: WO 02/04412 (2002-01-01), None
patent: WO 02/11722 (2002-02-01), None
patent: WO 02/012359 (2002-02-01), None
patent: WO 02/18321 (2002-03-01), None
patent: WO 02/18323 (2002-03-01), None
patent: WO 02/18363 (2002-03-01), None
patent: WO 02/26707 (2002-04-01), None
patent: WO 02/26743 (2002-04-01), None
patent: WO 02/28846 (2002-04-01), None
patent: WO 03/32916 (2003-04-01), None
patent: WO 03/033496 (2003-04-01), None
patent: WO 03/037328 (2003-05-01), None
patent: WO 03/82841 (2003-10-01), None
patent: WO 03/092679 (2003-11-01), None
patent: WO 04/041799 (2004-05-01), None
patent: WO 04/050646 (2004-06-01), None
patent: WO 04/062664 (2004-07-01), None
patent: WO 04/106305 (2004-12-01), None
Unterhalt et al., “Investigations of the cross reactivity of isothiazol-3(2 H)-one 1,1-dioxides,” Pharmazie, vol. 52, Iss. 11, pp. 764-766 (1998).
Arbuzov et al., “Reaction of azomethines with acylisocyanates in the presence of sulfur dioxide,”Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya(1980) 5:1164. (Abstract only).
Arbuzov et al., “Synthesis of substituted 4-oxo-1,2,3,5-oxathiadiazine 2-oxides,”Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya(1975) 6:1438. (Abstract only).
Beebe et al., “Substrate recognition through a PDZ domain in tail-specific protease,”Biochemistry(2000) 39:3149-3155.
Breslav et al., “Dithioketal formation during synthesis of Bpa containing peptides,”Tetrahedron Letters(1997) 38:2219.
Bright et al., “Competitive particle concentration fluorescene immunoassays for measuring anti-diabetic drug levels in mouse plasma,”J. of Immunological Methods(1997) 207:23.
Chou et al., “The syntheses of triazole, sulfur-containing diazole and N-phenylthiatriazole biphenyltetrazoles as potential angiotensin II receptor antagonists,”J. of the Chinese Chemical Society(1996) 43:83-93.
Davlatyan et al., “Reaction of thionylanilines with cyanohydrins and a-aminoisobutyronitrile,”Armyanskii Khimicheskii Zhurnal(1976) 29:764. (Abstract only).
Durcy et al., “Synthesis of 1,2,5-thiadiazolidin-3-one, 1,1-dioxide derivatives and evaluation of their affinity for MHC class-II proteins,”Helvetica Chemica Acta(1999) 82:2432.
Gao et al., “Macrocyclization in the design of a conformationally contrained Grb2 SH2 domain inhibitors,”Bioorganic&Medicinal Chemistry Letters(2001) 11:1889-1892.
Liu et al., “Small peptides containing phosphotyrosine and adjacent αMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2,”J. Med. Chem.(1999) 42:3737-3741.
Schoepfer et al. “Convergent synthesis of potent peptide inhibitors of the Grb-2-SH2 domain by palladium catalyzed coupling of a terminal alkyne,”Bioorganic&Medicinal Chemistry Letters(2001) 11:1201-1203.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitors of proteins that bind phosphorylated molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of proteins that bind phosphorylated molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of proteins that bind phosphorylated molecules will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3665452

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.