Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2005-12-07
2009-11-03
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C540S575000, C544S360000, C544S060000
Reexamination Certificate
active
07612200
ABSTRACT:
The present invention is directed to a compound having the formulawherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.
REFERENCES:
patent: 5569654 (1996-10-01), Armour et al.
patent: 5599930 (1997-02-01), Romero et al.
patent: 5696110 (1997-12-01), Bourrain et al.
patent: 5763437 (1998-06-01), Sato et al.
patent: 5942387 (1999-08-01), Hollinshead
patent: 6080763 (2000-06-01), Regan et al.
patent: 6187799 (2001-02-01), Wood et al.
patent: 6228881 (2001-05-01), Regan et al.
patent: 6242453 (2001-06-01), Cirillo et al.
patent: 6297381 (2001-10-01), Cirillo et al.
patent: 6329415 (2001-12-01), Cirillo et al.
patent: 6333325 (2001-12-01), Cirillo et al.
patent: 6358945 (2002-03-01), Breitfelder et al.
patent: 6372773 (2002-04-01), Regan
patent: 6492393 (2002-12-01), Breitfelder et al.
patent: 6506747 (2003-01-01), Betageri et al.
patent: 6506748 (2003-01-01), Hickey et al.
patent: 6525046 (2003-02-01), Cirillo et al.
patent: 6627629 (2003-09-01), Ko et al.
patent: 6656933 (2003-12-01), Hickey
patent: 2003/0069284 (2003-04-01), Keegan et al.
patent: 2003/0212070 (2003-11-01), Schwink et al.
patent: 2003/0225053 (2003-12-01), Gao et al.
patent: 2004/0122235 (2004-06-01), Polisetti et al.
patent: 2004/0259912 (2004-12-01), Matsumoto et al.
patent: 2005/0239841 (2005-10-01), Browning et al.
patent: 2006/0009453 (2006-01-01), Geuns-Meyer et al.
patent: 2006/0014761 (2006-01-01), Morgan et al.
patent: 2006/0069102 (2006-03-01), Leban et al.
patent: 2006/0167247 (2006-07-01), Michelotti et al.
patent: WO 98/52558 (1998-11-01), None
patent: WO 98/52559 (1998-11-01), None
patent: WO 99/32111 (1999-01-01), None
patent: WO 99/32110 (1999-07-01), None
patent: WO 99/32111 (1999-07-01), None
patent: WO 99/32463 (1999-07-01), None
patent: WO 00/41698 (2000-07-01), None
patent: WO 00/43384 (2000-07-01), None
patent: WO 00/55139 (2000-09-01), None
patent: WO 00/55152 (2000-09-01), None
patent: WO 01/36403 (2001-05-01), None
patent: WO 02/083628 (2002-10-01), None
patent: WO 02/083642 (2002-10-01), None
patent: WO 02/085859 (2002-10-01), None
patent: WO 02/092576 (2002-11-01), None
patent: WO 02/096876 (2002-12-01), None
patent: WO 02/098869 (2002-12-01), None
patent: WO 03/005999 (2003-01-01), None
patent: WO 03/049742 (2003-06-01), None
patent: WO 03/068229 (2003-08-01), None
patent: WO 03/068746 (2003-08-01), None
patent: WO 2004/056827 (2004-07-01), None
patent: WO 2004/060305 (2004-07-01), None
patent: WO 2004/060305 (2004-07-01), None
patent: WO 2004/060306 (2004-07-01), None
patent: WO 2004/060306 (2004-07-01), None
patent: WO 2004/061084 (2004-07-01), None
patent: WO 2004/061084 (2004-07-01), None
patent: WO 2004/089929 (2004-10-01), None
patent: WO 2004/111009 (2004-12-01), None
patent: WO 2005/014554 (2005-02-01), None
patent: WO 2005/023761 (2005-03-01), None
patent: WO 2005/023761 (2005-03-01), None
patent: WO 2005/110994 (2005-11-01), None
Attanasi, O.A., et al., “Conjugated Azoalkenes. Part 12. Synthesis of New 1-Amino-3-cyanopyrrole, 1,2-Diaminopyrrole and Pyrrolo[2,3-b]pyrrole Derivatives by Reaction of Some Conjugated Azoalkenes with Activated Nitriles,”J. Chem. Soc. Perkin Trans. 1:1009-1014, Journal of the Chemical Society (1992).
Burak, K., and Machon, Z., “Synthesis of isothiazole derivatives with potential biological activity,”Pharmazie 47:492-495, Govi-Verlag, Pharmazeutischer Verlag GmbH (1992).
Watt, A.P., et al., “Use of chiral liquid chromatography—tandom mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists,”J. Chromatogr. A 896:217-227, Elsevier Science B.V. (2000).
Search results of STN CHEMCATS Database, May 15, 2006 (American Chemical Society).
P38 Drug Discovery Program, Locus Pharmaceuticals, Nov. 2, 2004.
Wilson, K.P., et al., “Crystal Structure of p38 Mitogen-activated Protein Kinase,”J. Biol. Chem. 44:27696-27700, American Society for Biochemistry & Molecular Biology, Inc. (1996).
Co-pending U.S. Appl. No. 11/649,363, inventors Michelotti, E.L., et al., filed Jan. 4, 2007.
Michelotti Enrique Luis
Moore, Jr. William R.
Springman Eric Bruce
Locus Pharmaceuticals, Inc.
McDowell Brian
Pepper Hamilton LLP
Wilson James O
LandOfFree
Inhibitors of protein kinases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of protein kinases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of protein kinases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4085234