Inhibitors of proteasomal activity for stimulating hair growth

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S012200

Reexamination Certificate

active

06958220

ABSTRACT:
This inventions relates to compounds that inhibit the activity of the proteasome and both promotes hair growth and stimulates the production of hair follicles. The compounds provided herein are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

REFERENCES:
patent: 4761471 (1988-08-01), Urist
patent: 5280040 (1994-01-01), Labroo et al.
patent: 5580854 (1996-12-01), Orlowski et al.
patent: 5728844 (1998-03-01), Muller et al.
patent: 5767152 (1998-06-01), Nielsen et al.
patent: 5780454 (1998-07-01), Adams et al.
patent: 5824643 (1998-10-01), Pierce et al.
patent: 5910497 (1999-06-01), Durette et al.
patent: 5962301 (1999-10-01), Horvitz et al.
patent: 6083690 (2000-07-01), Harris et al.
patent: 6410512 (2002-06-01), Mundy et al.
patent: 6492333 (2002-12-01), Mundy
patent: 6495532 (2002-12-01), Bathurst et al.
patent: 2002/0107203 (2002-08-01), Mundy et al.
patent: 2002/0111292 (2002-08-01), Mundy et al.
patent: 197 16 713 (1998-10-01), None
patent: 0 931 544 (1999-07-01), None
patent: 05 097697 (1993-04-01), None
patent: WO 90 11366 (1990-10-01), None
patent: WO 92 03125 (1992-03-01), None
patent: WO 93 20859 (1993-10-01), None
patent: WO 93/25694 (1993-12-01), None
patent: WO 95 24211 (1995-09-01), None
patent: WO 95 25533 (1995-09-01), None
patent: WO 96/25946 (1996-08-01), None
patent: WO 96/33268 (1996-10-01), None
patent: WO 96 38590 (1996-12-01), None
patent: WO 97 09315 (1997-03-01), None
patent: WO 97 15308 (1997-05-01), None
patent: WO 97 23457 (1997-07-01), None
patent: WO 97 38699 (1997-10-01), None
patent: WO 97 48694 (1997-12-01), None
patent: WO 98 17267 (1998-04-01), None
patent: WO 98 25460 (1998-06-01), None
patent: WO 0002548 (2000-01-01), None
Abu-Amer et al., “NF-kB and Bone: The Breaking Point,” Nature Medicine (1997) 3(11):1189-1190.
Adams, J. et al., “Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents,” Cancer Res (1999) 59:2615-2622.
Adams et al., “Chapter 28. Novel Inhibitors of the Proteasome and their Therapeutic Use in Inflammation,” Annual Reports in Medicinal Chemistry (1996) 279-288.
Ahmed et al., “Alopecia Universalis Associated with a Mutation in the Human Hairless Gene,” Science (1998) 279:720-724.
Bangham et al., “Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids,” J Mol Biol (1965) 23:238-252.
Barnes et al., “Nuclear Factor -kB—A Pivotal Transcription Factor in Chronic Inflammatory Diseases,” New Engl J Med (1997) 336:1066-1071.
Baumeister et al., “The Proteasome:Paradigm of a Self-Compartmentalizing Protease,” Cell( 1998) 92:367-380.
Beck et al., “Rapid Publication TGF-β1Induces Bone Closure of Skull Defects,” J Bone Miner Res (1991) 6(11):1257-1265.
Bellows et al., “Determination of the Capacity for Proliferation and Differentiation of Osteoprogenitor Cells in the Presence and Absence and Absence of Dexamethasone,” Develop Biol (1990) 140:132-138.
Blessings et al., “Transgenic Mice as a Model to Study the Tole of TGF-β-Related Molecules in Hair Follicles,” Genes and Develop (1992) 7:204-215.
Burgener et al., “Fluoride Increase Tyrosine Kinase Activity in Osteoblast-like Cells: Regulatory Role for the Stimulation of Cell Proliferation and Pi Transport Across the Plasma Membrane,” J Bone Miner Res (1995) 10:164-171.
Caplan, “Mesenchymal Stem Cells” J Orthop Res (1991) 9:641-650.
Casez et al., “Dual-Energy X-Ray Absorptiometry for Measuring Total Bone Mineral Content in the Rat:Study of Accuracy and Precision,” Bone and Miner (1994) 26:61-68.
Combaret, L. et al., “Manipulation of the Ubiquitin-Proteasome Pathway in Cachexia: Pentoxifylline Suppresses the Activation of 20S and 26S Proteasoms in Muscles from Tumor-Bearing Rats,” Mol Biol Rep (1999) 26:95-101.
Coux, O. et al., “Structure and Functions of the 20S and 26S Proteasomes,” An Review Biochem (1996) 65:801-847.
Craiu, A. et al., “Lactacystin and Clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and major Histocompatibility Complex Class I Antigen Presentation,” J Biol Chem (1997) 272:13437-13445.
Cui et al., “Lovastatin Prevents Steroid-Induced Adipogenesis and Osteoporosis,” ASBMR 18th Annual Meeting (Sep. 1996) J Bone Miner Res (1996) 11(S1):S510.
Ducy et al. “Increased Bone Formation in Osteocalcin-deficient Mice,” Nature (1996) 382:448-425.
Edelman et al., “Controlled and Modulated Release of Basic Fibroblast Growth Factor,” Biomaterials (1991) 12:619-626.
Elofsson et al., Chemistry & Biology (1999) 6:811-822.
Ferretti, “Perspectives of pQct Technology Associated To Biomechanical Studies in Skeletal Research Employing Rat Models,” Bone (1995) 17:353S-364S.
Figueiredo-Pereira et al., “A New Inhibitor of the Chymotrypsin-Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin-Protein Conjugates in a Neuronal Cell,” J Neurochem (1994) 63:1578-1581.
Franzoso et al., “Requirement for NF-kB in Osteoclast and B-Cell Development,” Genes and Dev (1997) 11:3482-3496.
Garrett et al, “Specific Inhibitors of the Chymotryptic Component of the Proteasome are Potent Bone Anabolic Agents In Vivo” Journal of Bone and Mineral Research (2000) 15(Suppl.1)S197.
Gat et al., “De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin,” Cell (1998) 95:605-614.
Ghosh-Choudhery et al., “Immortalized Murine Osteoblasts Derived from BMP 2-T-Antigen Expressing Transgenic Mice,” Endocrinology (1996) 137:331-339.
Gowan et al., “Actions of Recombinant Interleukin 1, Interleukin 2, and Interferon-γ on Bone Resorption in Vitro,” J Immunol (1986) 136:2478-2482.
Groll et al., J. Am. Chem. Soc. (2000) 122:1237-1238.
Guijarro et al. “Lovastatin Inhibits Lipopolysaccharide-induced NF-kB Activation in Human Mesangial Cells,” Nephrol Dial Transplant (1996) 11:990-996.
Gupta et al., “Oral Cyclosporine for the Treatment of Alopecia Areata,” J Amer Acad of Dermatology (1990) 22(2):242-250.
Hardy et al., “The Secret Life of the Hair Follicle,” Trans Genet (1992) 8:55-61.
Harris et al. “Effects of Transforming Growth Factor β on Bone Nodule Formation and Expression of Bone Morphogenetic Protein 2, Osteocalcin, Osteopontin, Alkaline Phosphatase, and Type I Collagen mRNA in Long-Term Cultures of Fetal Rat Calvarial Osteoblasts,” J Bone Miner Res (1994) 9:855-863.
Hilt, W. et al., “Proteasomes: Destruction as a Programme,” Trans Biochem Sci 91996) 21:96-101.
Iotsova et al., “Osteopetrosis in Mice Lacking NF-kB1 and NF-kB2,” Nature Med (1997) 3:1285-1289.
Jensen, T.J. et al., “Multiple Proteolytic Systems, Including the Proteasome, Contribute to CFTR Processing,” Cell (1995) 83:129-135.
Kamiya et al., J. Derm. Sci. (1998) 17:54-60.
Kim et al., “Preparation of Multivesicular Liposomes,” Biochim Biophys Acta (1983) 728:339-348.
Kimmel et al., “The Effect of Recombinant Human (1-84) or Synthetic Human (1-34) Parathyroid Hormone on the Sleeton of Adult Osteopenic Ovariectomized Rats,” Endocrinology (1993) 132:1577-1584.
Ksander et al., “Exogenous Transforming Growth Factor-Beta 2 Enhances Connective Tissue Formation and Wound Strength in Guinea Pig Dermal Wounds Healing by Secondary Intent,” Ann Surg (1990) 211(3):288-294.
Laval-Jeantet et al., “Dual-EnergyX-Ray Absorptiometry of the Calcaneus: Comparison with Vertebral Dual-Energy X-Ray Absorptiometry and Quantitative Computed Tomography,” Calcif Tissue Intl (1995) 56:14-18.
Law et al., Mol. Cell Biol. (1992) 12:103-111.
Leserman et al., “Targeting to Cells of Fluorescen

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitors of proteasomal activity for stimulating hair growth does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of proteasomal activity for stimulating hair growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of proteasomal activity for stimulating hair growth will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3473017

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.