Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-10-01
2000-10-03
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5462741, 5462744, 5462751, A61K 3144, C07D40106
Patent
active
061273902
ABSTRACT:
The present invention is directed to compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
REFERENCES:
patent: 4074051 (1978-02-01), Stevens et al.
patent: 4287195 (1981-09-01), Heeres et al.
patent: 4329470 (1982-05-01), Grisar et al.
patent: 4713387 (1987-12-01), Wantanabe et al.
patent: 4826835 (1989-05-01), Kuhla et al.
patent: 4914207 (1990-04-01), Nagel et al.
patent: 5428164 (1995-06-01), Thurkauf et al.
patent: 5441970 (1995-08-01), Reitz et al.
patent: 5478934 (1995-12-01), Yuan et al.
patent: 5491164 (1996-02-01), DeSolms et al.
patent: 5578629 (1996-11-01), Ciccarone et al.
patent: 5616601 (1997-04-01), Khanna et al.
patent: 5627202 (1997-05-01), deSolms
patent: 5646280 (1997-07-01), Thurkauf et al.
patent: 5652257 (1997-07-01), Anthony et al.
patent: 5656762 (1997-08-01), Thurkauf et al.
patent: 5710171 (1998-01-01), Dinsmore et al.
Chem. abstr., vol. 111, No. 21, p. 742, col. 1, No. 194444b, (1989), O. Shimomura, et al.
Chem. abstr., vol. 109, No. 15, p. 106, col. 2, No. 122899q, (1988), A. Patel, et al.
Chem. abstr., vol. 109, No. 13, p. 618, col. 1, No. 110370x, (1988), A.M. Tikdari, et al.
Chem. abstr., vol. 109, No. 10, p. 101, col. 2, No. 79568s, (1988), G. Bettinetti, et al.
Chem. abstr., vol. 110, No. 9, p. 652, col. 1, No. 75494n, (1989), A.H. Robins, Co., Inc.
Chem. abstr., vol. 110, No. 11, p. 740, col. 2, No. 95589a, (1989), U. Holgrabe, et al.
Chem. abstr., vol. 110, No. 13, p. 688, col. 1, No. 114776c, (1989), C.G. Wermuth, et al.
Chem. abstr., vol. 110, No. 13, p. 742, col. 2, No. 115292d, (1989), P.D. Leeson, et al.
Chem. abstr., vol. 110, No. 21, p. 721, col. 1, No. 192538r, (1989), R.L. Tolman et al.
Chem. abstr., vol. 110, No. 23, p. 748, col. 1, No. 212763r, (1989), J.C. Lancelot, et al.
Chem. abstr., vol. 110, No. 25, p. 627, col. 2, No. 231448h, (1989), Y. Nezu, et al.
Chem. abstr., vol. 111, No. 1, p. 702, col. 1, No. 7319e (1989), N.G. Kandile, et al.
Chem. abstr., vol. 112, No. 23, p. 697, col. 2, No. 217449u, (1990), B. Kaskar,, et al.
Chem. abstr., vol. 112, No. 13, p. 286, col. 2, No. 114120a, (1990), K.H. Chung, et al.
Chem. abstr., vol. 112, No. 1, p. 773, col. 1, No. 7857z, (1990), H. Ishitsuka.
Chem. abstr., vol. 111, No. 11, p. 729, col. 1, No.97094e, (1989), T. Hamazaki, et al.
Chem. abstr., vol. 111, No. 9, p. 727, col. 2, No. 77745q, (1989), K.A. Jacobson, et al.
Exp. Opin. Ther. Patents, vol. 6, No. 12, pp. 1295-1304 (1996), by S. Graham, et al.
Exp. Opin. Ther. Patents, vol. 5, No. 12, pp. 1269-1285 (1995), by S. L. Graham.
Cancer Research, vol. 55, pp. 5302-5309 (1995), by L. Sepp-Lorenzino, et al.
Nature Medicine, vol. 1, No. 8, pp. 792-797 (1995), by N. Kohl, et al.
Proc. Natl. Acad. Sci. USA, vol. 91, pp. 9141-9145 (1994), by N. Kohl, et al.
Science, vol. 260, pp. 1934-1937 (1993), by N. Kohl, et al.
J. of Biol. Chem., vol. 270, No. 11, pp. 6221-6226 (1995), by G. James, et al.
J. of Biol. Chem., vol. 269, No. 44, pp. 27705-27714 (1994), by G. James, et al.
J. of Biol. Chem., vol. 265, No. 11, pp. 7617-7620 (1993), by J. Gibbs, et al.
Payne, et al., Database Caplus On Stn, DN:126:31349.
Derwent Abst. 90-318321/42 (Takeda) abstract of JP 02229169.
Matsuzaka, et al. CA 99:203546, 1983.
deSolms S. Jane
Lumma, Jr. William C.
Shaw Anthony W.
Sisko John T.
Tucker Thomas J.
Daniel Mark R.
Fan Jane
Merck & Co. , Inc.
Muthard David A.
LandOfFree
Inhibitors of prenyl-protein transferase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of prenyl-protein transferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of prenyl-protein transferase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-196097