Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-04
1996-12-24
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514617, 514619, A61K 31165, A61K 3147
Patent
active
055873847
ABSTRACT:
Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.
REFERENCES:
Banasik et al., J. Biol. Chem (1992), 267(3), 1569-75.
Wallis et al., "Neuroprotection Against Nitric Oxide Injury with Inhibitors of ADP-ribosylation", Neuropharmacology and Neurotoxicology 5(3):245-248 (1993).
Dawson et al., "Nitric Oxide Mediates Glutamate Neurotoxicity in Primary Cortical Cultures" Proc. Natl. Acad. Sci. 88:6368-6371 (1991).
Nowicki et al. "Nitric Oxide Mediates Neuronal Death After Focal Cerebral Ischemia in the Mouse", European J. Pharmacology 204:339-340 (1991).
Dawson et al., "Mechanisms of Nitric Oxide-Mediated Neurotoxicity in Primary Brain Cultures", J. Neuroscience 13(6):2651-2661 (1993).
Purnell et al., "Novel Inhibitors of Poly(ADP-Ribose) Synthetase", Biochem J. 185:775-777 (1980).
Banasik et al., "Specific Inhibitors of Poly(ADP-Ribose) Synthetase and Mono(ADP-Ribosyl) Transferase", J. Biol. Chem. 267(3):1569-1575 (1992).
Zhang et al., "Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity" Science 263:687-689 (1994).
Dawson Ted M.
Dawson Valina L.
Snyder Solomon H.
Zhang Jie
Spivack Phyllis G.
The Johns Hopkins University
The United States of America
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