Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-12-17
1993-08-24
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514246, 544180, 548427, 548451, 548475, 548477, A61K 3140, C07D20948
Patent
active
052389502
ABSTRACT:
A method of inhibiting the binding of PDGF using compounds of the formula I ##STR1## useful in the treatment of atherosclerosis, cancer, retinal detachment, pulmonary fibrosis, arthritis, psoriasis and glomerulonephritis, and restenosis following angioplasty or vascular surgery is disclosed.
Also disclosed are pharmaceutical compositions and novel PDGF inhibitory compounds of the formula ##STR2## or a pharmaceutically acceptable addition salt thereof, useful in the treatment of atherosclerosis, cancer, retinal detachment, pulmonary fibrosis, arthritis, psoriasis and glomerulonephritis, and restenosis following angioplasty or vascular surgery.
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Lukovits, Chemical Abstract, vol. 110(111, 1988, #87980f).
Soai, et al., Bull. Chem. Soc. Jpn., 55 1982) 1671-1672.
Ferns, et al., Science, 253 (1991) 1129-1132.
Clader John W.
Davis Harry R.
Mullins Deborra
Rosenblum Stuart
Weinstein Jay
Gupta Y. N.
Magatti Anita W.
Schering Corporation
Shah Mukund J.
Thompson Paul A.
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