Inhibitors of platelet binding

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514822, 514929, 530326, A61K 3700, C07K 100

Patent

active

051698366

ABSTRACT:
Peptides comprising the tripeptide sequence of arginine-tyrosine-aspartic acid, linked from amino- to carboxy-terminus, are inhibitors of fibrinogen binding, platelet aggregation, glycoprotein IIb-IIIa binding and related aberrant and normal physiological conditions.

REFERENCES:
patent: 4244946 (1981-01-01), Rivier et al.
patent: 4305872 (1981-12-01), Johnston et al.
patent: 4316891 (1982-02-01), Guillemin et al.
patent: 4578079 (1986-03-01), Ruslahti et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4769239 (1988-09-01), Ellis et al.
Auffray et al. Human Immun. vol. 15 381-390 (1986).
Rao et al., Biochem. vol. 26 3556-3564 (1987).
Titani et al., Biochem. vol. 25, 3171-3184 (1986).
Shattil et al., J. Biol. Chem. vol. 260 No. 20, (1985) 11107-11114.
Geliebter, Focus vol. 9: 5-8 (1987).
Tachibana et al., JP 51082710 (1976-Abstract).
Rudinger, Peptide Hormones (Jun. 1976) 1-6.
Chen et al., Virology vol. 155 106-119 (1986).
Bodansky, M., ed., Principles of Peptide Synthesis, Springer-Verlag, (1984).
Gennaro, A. R., ed., Remington's Pharmaceutical Sciences, (Mack Publishing Co., Easton, Pa. 1985).
Gross and Mienhofer, eds., The Peptides, vol. 3, pp. 3-88 (Academic Press, NY, 1981).
Kabat, E. A., et al., Sequences of Proteins of Immunologic Interest, (US, DHHS, PHS, NIH 1987).
Maniatis et al., Molecular Cloning, A Laboratory Manual, (Cold Spring Harbour 1982).
Segal, Enzyme Kinetics, 465-504 (Wiley-Interscience, NY 1975).
Ross and Aviv et al., "In Vitro Synthesis of DNA Complementary to Purified Rabbit Globin mRNA 38 , Proc. Natl. Acad. Sci., 69: 264-268 (1972).
Rouslahti et al., "New Perspectives in Cell Adhesion: RGD and Integrins 38 , Science, 238: 491-497 (1987).
Shlomchik et al., "Variable Region Sequences of Murine IgM Anti-IgG Monoclonal Autoantibodies", J. Exp. Med., 164: 407-427 (1986).
Shattil et al., "Detection of Activated Platelets in Whole Blood Using Activation-Dependent Monoclonal Antibodies and Flow Cytometry 38 , Blood, 70: 307-315 (1987).
Shattil et al., "Expression fo Fibrinogen Receptors During Activation and Subsequent Desenitization of Human Platelets by Epinephrine", Blood, 68: 1224-1231 (1986).
Tam et al., "S.sub.N 2 Deprotection of Synthetic Peptides with a Low Concentration of HF in Dimethyl Sulfide: Evidence and Application in Peptide Synthesis", J. Am. Chem. Soc., 105: 6442-6455 (1983).
Vale et al., "Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and .beta.-Endorphin", Science, 213: 1394-1397.
Kohler et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature, 256: 495-497 (1975).
McEver et al., "A Monoclonal Antibody to a Membrane Glycoprotein Binds Only to Activated Platelets", J. Biol. Chem., 259: 9799-9804 (1984).
Marguerie et al., "Human Platelets Possess an Inducible and Saturable Receptor Specific for Fibrinogen", J. Biol. Chem., 254: 5357-5363 (1979).
Marki et al., "Total Solid-Phase Synthesis of Porcine Gut Gastrin Releasing Peptide (GRP), a Mammalian Bombesin", J. Am. Chem. Soc., 103: 3178-3185 (1981).
Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Am. Chem. Soc., 85: 2149-2154 (1963).
Phillis et al., "The Platelet Membrane Glycoprotein IIb-IIIa Complex", Blood, 71: 831-843 (1988).
Pytela et al., "Platelet Membrane Glycoprotein IIb/IIIa:Member of a Family of Arg-Gly-Asp-Specific Adhesion Receptors", Science, 231: 1559-1562 (1986).
Riechmann et al., "Reshaping Human Antibodies for Therapy", Nature, 332: 323-327 (1988).
Rivier et al., "Peptide and Amino Acid Analysis By RP-HPLC", Peptides: The structure and Biological Function, 125-128 (1979).
Haverstick et al., "Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen, and von Willebrand Factor Substrates by a Synthetic Tetrapeptide Derived from the Cell Binding Domain of Fibronectin", Blood, 66:946-952 (1985).
Houghten, "General Method for the Rapid Solid-phase Synthesis of Large Numbers of Peptides: Specificity of antigen-antibody interaction at the level of individual amino acids", Proc. Natl. Acad. Sci. U.S.A., 82: 5131-5135 (1985).
Humphries et al., "Identification of an Alternatively Spliced Site in Human Plasma Fibronectin That Mediates Cell Type-specific Adhesion", J. Cell Biol., 103: 2637-2647 (1986).
Hynes, "Integrins: A Family of Cell Surface Receptors", Cell, 48: 549-554 (1987).
Kloczewiak et al., "Platelet Receptor Recognition Site on Human Fibrinogen. Synthesis and Structure-Function Relationship of Peptides Corresponding to the Carboxy-Terminal Segment of the .gamma. Chain", Biochemistry, 23: 1767-1774 (1984).
Kloczewiak et al., "Recognition Site for the Platelet Receptor is Present on the 15-Residue Carboxy-Terminal Fragment of the .gamma.Chain of Human Fibrinogen and is Not Involved in the Fibrin Polymerization Reaction," Thrombosis Res., 29: 249-255 (1983).
Abrams et al., "Platelet Activation and Fragmentation During Cardiopulmonary Bypass Can be Detected by Flow Cytometry of Whole Blood", Blood, 70: 335a (1987).
Bennett et al., "Interaction of Fibrinogen with Its Platelet Receptor", J. Biol. Chem., 263: 1-6 (1988).
Bennett et al., "Exposure of Platelet Fibrinogen Receptors by ADP and Epinephrine", J. Clin. Invest., 64: 1393-1401 (1979).
Bennett et al., "Inhibition of Fibrinogen Binding to Stimulated Human Platelets by a Monoclonal Antibody", Proc. Natl. Acad. Sci. U.S.A., 80: 2417-2421 (1983).
Chirgwin et al., "Isolation of Biologically Active Ribonucleic Acid from Sources Enriched in Ribonucleases", Biochemistry, 18: 5294-5299 (1979).
Gartner et al., "The Tetrapeptide Analogue of the Cell Attachment Site of Fibronectin Inhibits Platelet Aggregation and Fibrinogen Binding to Activated Platelets", J. Biol. Chem., 260: 11891-11894 (1985).
Ginsberg et al., "Inhibition of Fibronectin Binding to Platelets by Proteolytic Fragments and Synthetic Peptides Which Support Fibroblast Adhesion", J. Biol. Chem., 260:3931-3936 (1985).
Bennett et al., "Interaction of Fibrinogen with Its Platelet Receptor", J. Biol. Chem., vol. 263, No. 26, pp. 12948-12953 (1988).
Goetinck et al., "The Tandemly Repeated Sequences of Cartilage Link Protein Contain the Sites for Interaction with Hyaluronic Acid", J. Cell Biol., vol. 105, pp. 2403-2408 (1987).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitors of platelet binding does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of platelet binding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of platelet binding will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-961096

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.