Inhibitors of plant peptide deformylase for use as...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S006120, C435S069100, C435S183000, C435S200000, C435S320100, C435S252300, C536S023200, C536S023400, C536S023500, C536S023600

Reexamination Certificate

active

07419815

ABSTRACT:
The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides.

REFERENCES:
patent: 5985273 (1999-11-01), Reed et al.
patent: 0911409 (1999-04-01), None
patent: 1033405 (2000-09-01), None
Braun et al. Purification and sequencing of cytochrome b from potato reveals methionine cleavage of mitochondrially encoded protein, FEBS Letters 316: 128-132, 1993.
Akers, Alan, “Molecular Biology as Virtual Biology: Limitations of Molecular Biology in Pesticide Discovery”, 1996, pp. 85-91, vol. 46, Pesticide Science, Great Britain.
Chen et al., “Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor”, Biochemistry 2000, 2000, pp. 1256-1262, American Cancer Society, Washington, DC.
Giglione et al., “Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents”, MicroReview, Molecular Microbiology, 2000, 36(6):1197-1205, Blackwell Science, Ltd., Oxford, England.
Giglione et al., “Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms”, The EMBO Journal, Sep. 13, 2000, pp. 5916-5929, vol. 19, No. 21, European Molecular Biology Organization, France.
Meinnel, T., “Peptide Deformylase of Eukaryotic Protists: A Target for New Antiparasitic Agents?”, Parasitology Today, 2000, pp. 165-168, vol. 16, No. 4, Elsevier Science, Ltd., Oxford, England.

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