Inhibitors of p38

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S187000, C514S235200, C546S143000, C546S144000, C546S023000, C544S128000, C544S365000

Reexamination Certificate

active

07423049

ABSTRACT:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

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Brunet et al., Essays Biochem. 32: 1-16, 1997 (Abstract).
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Herlaar et al., Mol. Med. Today 5(10) 439-447, 1999 (Abstract).
Graninger et al., Curr. Opin. Rheumatol. 13(3):209-13, 2001 (Abstract).

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