Inhibitors of p38

Details Inhibitors of p38 Inhibitors of p38

2007-01-30

2007-01-30

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S253010, C514S332000, C514S343000, C514S352000, C544S124000, C544S360000, C546S265000, C546S276400, C546S309000

Reexamination Certificate

active

10658111

ABSTRACT:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

REFERENCES:
patent: 2004/0044002 (2004-03-01), Cochran et al.
patent: WO 98/27098 (1998-06-01), None
Damsasio, Alzheimer's Disease and Related Dementias, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1992-1996, 1996.
Laszlo et al., “Pyrroles and Other Heterocycles as Inhibitors of p38 Kinsase” Biorganic & Medicinal Chemistry Letters, 8(19), pp. 2689-2694, 1998.
Layzer, “Degenerative Diseases of the Nervous System”, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 2050-2057, 1996.
Simone, “Oncology: Introduction”, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.

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