Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-18
2007-09-18
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S345000, C514S349000, C514S350000, C514S231500, C514S252100, C546S268100, C546S290000, C546S297000, C544S111000, C544S359000
Reexamination Certificate
active
10144153
ABSTRACT:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
REFERENCES:
patent: 3499898 (1970-03-01), Thiele et al.
patent: 3506668 (1970-04-01), Lesher
patent: 3819639 (1974-06-01), Delarge et al.
patent: 4973690 (1990-11-01), Rempfler et al.
patent: 5498609 (1996-03-01), Ogawa et al.
patent: 5677299 (1997-10-01), Ogawa et al.
patent: 5753648 (1998-05-01), Albright et al.
patent: 6316474 (2001-11-01), McCauley et al.
patent: 6586423 (2003-07-01), Bilodeau et al.
patent: 6586424 (2003-07-01), Bilodeau et al.
patent: 6919336 (2005-07-01), Révész
patent: WO97/09325 (1997-03-01), None
patent: WO99/58502 (1999-11-01), None
patent: WO01/17995 (2001-03-01), None
patent: WO01/32174 (2001-05-01), None
patent: WO02/076447 (2002-10-01), None
Graninger et al. Curr. Opin. Rheumatol. 13(3): 209-213,2001.
Brunet et al., Esaays Biochem. 32 : 1-16, 1997.
Nagarkatti et al. J. Mol. Cell Cardiol. 30(8): 1651-1664, 1998.
Herlaar et al. Mol. Med. Today 5(10) 439-447,1999.
Jefferson, W. Tilley et al., “A Palladium-Catalyzed Carbonyl Insertion Route to Pyrido[2,1-b]quinazoline Derivatives,” J. Org. Chem., 52, 2469-2474 (1987).
V. P. Arya et al., Ind. J. Chem. Sect. B, 15, 1129-1132 (1977), Beilstein Registry No. 819099, 824847.
W. H. Nyberg et al., J. Het. Chem., 1, 1-5 (1964), Beilstein Registry No. 531011, 532897.
Korytnyk et al., “Guanylhydrazones with Potential Antileukemic Activity. 1. Aza Analogs of 4,4′-Diacetyldiphenylurea Bis (guanylhydrazone)”,Journal of Medicinal Chemistry, 1973, vol. 16, No. 8, pp. 959-961.
Nyberg et al., Beilstein Registry No. 521505.
Wright et al., Beilstein Registry Nos. 7989593, 7990821, 8000138.
Gueremy et al., “2-Amino-6-chloro-4-(N-methylpiperazino) pyrimidines, Inhibitors of Spiroperidol Binding”,Journal of Medicinal Chemistry, 1982, vol. 25, pp. 1459-1465.
Revesz et al., “SAR of benzoylpyridines and penzophenones as p38α MAP kinase inhibitors with oral activity”, Bioorganic & Medicinal Chemistry Letters, 2004, vol. 14, pp. 3601-3605.
Cochran John E
Green Jeremy
Harbeson Scott L
Balasubramanian Venkataraman
Haley Jr. James F.
Roise David A.
Ropes & Gray LLP
Vertex Pharmaceuticals Incorporated
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