Inhibitors of p38

Details Inhibitors of p38 Inhibitors of p38

2006-10-03

2006-10-03

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S336000, C514S183000, C514S218000, C514S231500, C514S252130, C546S282100, C546S288000, C546S289000, C544S111000, C544S360000, C540S470000, C540S575000

Reexamination Certificate

active

07115637

ABSTRACT:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

REFERENCES:
patent: 0337943 (1989-10-01), None
patent: 0337944 (1989-10-01), None
patent: WO 97/33883 (1997-09-01), None
patent: WO 98/27098 (1998-06-01), None
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition, vol. 1, 1004-1010, 1996.
Brunet et al., Esaays Biochem. 32: 1-16, 1997.
Nagarkatti et al., J. Mol. Cell Cardiol. 30(8): 1651-1664, 1998.
Herlaar et al., Mol. Med. Today 5(10) 439-447, 1999.
Graninger et al., Currr. Opin. Rheumatol. 13(30: 209-13, 2001.

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