Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-10
2000-11-14
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514247, 514248, 514267, 514351, 514357, 514243, 544234, 544236, 544239, 544252, 544282, 544184, 546300, 546333, A61K 31519, C07D47104
Patent
active
061470805
ABSTRACT:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The compounds are of the class of pyrido [1,2-c] pyrimidin-3-one or 1,2-dihydro-pyrido [1,2-c] pyrimidin-3-one derivatives, useful as inhibitors of p38. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
REFERENCES:
patent: 5716955 (1998-02-01), Adams et al.
patent: 5716972 (1998-02-01), Adams et al.
patent: 5717100 (1998-02-01), Selnick et al.
patent: 5945418 (1999-08-01), Bemis et al.
Timothy F. Gallagher, et al., "Regulation of Stress-Induced Cytokine Production by Pyridinylimidazoles; Inhibition of CSBP Kinase," Bioorganic & Medicinal Chemistry, 5(1), pp. 49-64, (1997).
Alison M. Badger, et al., "Pharmacological Profile of SB 203580, a Selective Inhibitor of Cytokine Suppressive Binding Protein/p38 Kinase, in Animal Models of Arthritis, Bone Resorption, Endotoxin Shock and Immune Function," Journal of Pharmacology and Experimental Therapeutics, 279(3), pp. 1453-1461, (1996).
Timothy F. Gallagher, et al., "2,4,5-Triarylimidazole inhibitors of IL-1 Biosynthesis," Bioorganic & Medicinal Chemistry Letters, 5 (11), pp. 1171-1176, (1995).
Bemis Guy W.
Duffy John Patrick
Harrington Edmund Martin
Salituro Francesco Gerald
Bernhardt Emily
Govindaswamy N.
Haley, Jr. James F.
Vertex Pharmaceuticals Incorporated
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