Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-06-27
2000-07-25
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564 48, 564 49, 564 50, 564 26, 514585, 514597, 514598, A61K 3117, C07C27528
Patent
active
060937424
ABSTRACT:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
REFERENCES:
patent: 5716972 (1998-02-01), Adams et al.
patent: 5807876 (1998-09-01), Armistead
patent: 5843904 (1998-12-01), Bemis et al.
Blum-Degen et al., Interleukin-1B and Interleukin-6 are Elevated in the Cerebrospinal Fluid of Alzheimer's and de novo Parkinson's Disease Patients, Neurosci. Lett. 202, 17-20 (1995).
Kumar et al., Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase, J. Biol. Chem. 271, 30864-69 (1996).
Bemis Guy W.
Green Jeremy
Kofron James L.
Salituro Francesco Gerald
Awlakh Charanjit S.
Brown Karen E.
Haley, Jr. James F.
Kight John
Vertex Pharmaceuticals Inc.
LandOfFree
Inhibitors of p38 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of p38, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of p38 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1336982