Inhibitors of p38

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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564 48, 564 49, 564 50, 564 26, 514585, 514597, 514598, A61K 3117, C07C27528

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active

060937424

ABSTRACT:
The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

REFERENCES:
patent: 5716972 (1998-02-01), Adams et al.
patent: 5807876 (1998-09-01), Armistead
patent: 5843904 (1998-12-01), Bemis et al.
Blum-Degen et al., Interleukin-1B and Interleukin-6 are Elevated in the Cerebrospinal Fluid of Alzheimer's and de novo Parkinson's Disease Patients, Neurosci. Lett. 202, 17-20 (1995).
Kumar et al., Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase, J. Biol. Chem. 271, 30864-69 (1996).

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