Inhibitors of P2X 3

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S121000, C544S357000, C544S364000, C544S369000, C544S371000, C544S386000, C544S391000, C544S362000, C544S237000, C544S250000, C544S330000, C544S331000, C546S209000, C546S212000, C546S214000

Reexamination Certificate

active

07491821

ABSTRACT:
Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genitourinary, gastrointestinal, and respiratory disorders:whereinR1is —C(═S)CH3, pyridyl, pyrimidinyl, pyrazinyl, thiazolyl, furyl, furylcarbonyl, acetyl, or carbamoyl; R2aand R2bare independently H, methyl, or ethyl; R3is H or methyl; Y is a bond, —(CR4R5)n— or —CR4═CR5—; wherein R4and R5are each independently H or methyl and n is 1 or 2; X is N or CH; A is phenyl, 5-membered heterocyclyl, or 6-membered heterocyclyl; R6, R7and R8are each independently H, halo, lower alkyl, cycloalkyl, alkylthio, alkylthio-lower alkyl, alkylsulfonyl-lower alkyl, di(lower alkyl)amino-lower alkyl, morpholinyl-lower alkyl, 4-methyl-piperazinyl-methyl, trifluoromethyl, pyridyl, tetrazolyl, thiophenyl, phenyl, biphenyl, or benzyl (where thiophenyl, phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoromethyl, lower alkoxy or lower alkylthio) or R6and R7together form a 5-membered or 6-membered carbocyclic or heterocyclic ring substituted with 0-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, oxo, halo, thiophenyl-lower alkyl, phenyl, benzyl (where phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoro-methyl, lower alkoxy, lower alkylthio, amino-lower alkyl, lower alkylamino-lower alkyl, or di(lower alkyl)amino-lower alkyl); and pharmaceutically acceptable salts thereof; wherein when R1is pyrimidin-2-yl, X is N, Y is a bond and A is oxazol-5-yl the carbon atom at position 4 in said oxazol-5-yl is not substituted by propyl when the carbon atom at position 2 in said oxazol-5-yl is substituted by substituted phenyl and the carbon atom at position 4 in said oxazol-5-yl is not substituted by phenyl when the carbon atom at position 2 is substituted by unsubstituted or substituted phenyl.

REFERENCES:
patent: 3705899 (1972-12-01), Regnier et al.
patent: 5696267 (1997-12-01), Reichard et al.
patent: 5840725 (1998-11-01), Reichard et al.
patent: 5945428 (1999-08-01), Shih et al.
patent: 5985603 (1999-11-01), Valera et al.
patent: 6133434 (2000-10-01), Buell et al.
patent: 6194162 (2001-02-01), Valera et al.
patent: 6239134 (2001-05-01), Sabb et al.
patent: 2003/0083359 (2003-05-01), Lee et al.
patent: 2004/0023203 (2004-02-01), Miesenbock et al.
patent: 2004/0029887 (2004-02-01), Bhatia et al.
patent: 2004/0067967 (2004-04-01), Barden et al.
patent: 0 395 313 (1990-04-01), None
patent: 0 462 638 (1991-12-01), None
patent: 0 709 375 (1996-05-01), None
patent: 0 474 561 (1998-12-01), None
patent: 2 303 303 (1997-02-01), None
patent: 61 100566 (1986-05-01), None
patent: WO 99/03833 (1999-01-01), None
patent: WO 00/51999 (2000-09-01), None
patent: WO 00/52002 (2000-09-01), None
patent: WO 00/63379 (2000-10-01), None
patent: WO 02/094767 (2002-11-01), None
patent: WO 02/094767 (2002-11-01), None
patent: WO 03/099266 (2003-12-01), None
patent: WO 03/099266 (2003-12-01), None
Drugarin et al. Chemical Abstracts, vol. 96, No. 85515 (1982).
Bian, X., et al “Peristalsis is impaired in the small intestine of mice lacking the P2X3subunit”,J. Physiol(2003) 551.1, 309-322.
Brouns, I., eg al, “Intraepithelial Vagal Sensory Nerve Terminals in Rat Pulmonary Neuroepithelial Bodies Express P2X3Receptors”,Am. J. Respir. Cell Mol. Biol. (2000) vol. 23, 52-61.
King, B.F., et al., “Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red”Brit Jnl Pharm(2005) 145, 313-322.
Rong, W., et al., “Pivotal Role of Nucleotide P2X2Receptor Subunit of the ATP-Gated Ion Channel Mediating Ventilatory Responses to Hypoxia”,Jnl Neuroscience, (Dec. 10, 2003) 23(36), 11314-11321.
Wynn, G., et al., “Purinergic component of mechanosensory transduction is increased in a rat model of colitis”,AJP-Gastro Liver Physio, (2004) 287:647-657.
Yiangou, Y., et al., “ATP-gated ion channel P2X3 is increased in human inflammatory bowel disease”,Neurogastroenterol Mot., (2001) 13, 365-369.
C. Drugarin et al., “Synthese ellniger neuer Piperazinderivate”, Pharmazie (1981) 36:709-10.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitors of P2X 3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of P2X 3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of P2X 3 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4077397

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.