Inhibitors of oligosaccharyl transferase

Details Inhibitors of oligosaccharyl transferase Inhibitors of oligosaccharyl transferase

1995-12-07

1998-02-24

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530322, C07K 502, C07K 5037, A61K 3812

Patent

active

057213380

ABSTRACT:
The present invention provides novel inhibitors of oligosaccharyl transferase, methods for producing Glc.sub.3 Man.sub.9 (GlcNAc).sub.2 -P-P-Dol, and methods for producing glycopeptides.

REFERENCES:
patent: 4330624 (1982-05-01), Tejera et al.
Hendrickson, T. L.; Imperiali, B. "Metal Ion Dependence of Oligosaccharyl Transferase: Implications for Catalysis," Biochemistry 1995, 34, 9444.
Imperiali, B.; Rickert, K. W. "Conformational implications of asparagine-linked glycosylation," Proc. Natl. Acad. Sci. USA 1995, 92, 97.
Imperiali, B.; Spencer, J.R.; and Struthers, M. D. "Structural and Functional Characterization of a Constrained Asx-Turn Motif," J. Am. Chem. Soc. 1994, 116, 8424.
Imperiali, B; Shannon, K. L.; and Rickert, K. W. "Role of Peptide Conformation in Asparagine-Linked Glycosylation," J. Am. Chem Soc. 1992, 114, 8642.
Hendrickson, T. L.; Sepncer, J. R., Kato, M. et al. "Design and Evaluation of Potent Inhibitors of Asparagine-Linked Protein Glycosylation," J. Am. Chem Soc. 1996, 118, 7636.

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