Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Separation or purification
Patent
1997-08-19
1999-11-30
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Separation or purification
530412, 530317, 530322, C07K 114, C07K 502, C07K 5037
Patent
active
059945028
ABSTRACT:
The present invention provides novel inhibitors of oligosaccharyl transferase, methods for producing Glc.sub.3 Man.sub.9 (GlcNAc).sub.2 --P--P--Dol, and methods for producing glycopeptides.
REFERENCES:
Tamara, G., ed., Table of Contents, Tunicamycin, (Japan Scientific Societies Press, 1986), pp. viii-xii.
Imperiali, Barbara and Karen L. Shannon, "Differences between Asn-Xaa-Thr-Containing Peptides: A Comparison of Solution Conformation and Substrate Behavior with Oligosaccharyltransferase," Biochemistry, vol. 30, No. 18, 1991, pp. 4374-4380.
Imperiali, Barbara et al., "Structural and Functional Characterization of a Constrained Asx-Turn Motif," J. Am. Chem. Soc., vol. 116, No. 18, 1994, pp. 8424-8425.
Imperiali, B. et al., "A Mechanistic Proposal for Asparagine-Linked Glycosylation," Reprinted from the Journal of the American Chemical Society, 1992, 114.
Welply, Joseph K. et al., "Substrate Recognition by Oligosaccharyltransferase," The Journal of Biological Chemistry, vol. 258, No. 19, Oct. 10, 1983, pp. 11856-11863.
Ronin, Catherine et al., "Synthetic Substrates for Thyroid Oligosaccharide Transferase," Eur. J. Biochem, vol. 118, 1981, pp. 159-164.
Oda-Tamai, Sachie et al., "Decreased Transfer of Oligosaccharide from Oligosaccharide-Lipid to Protein Acceptors in Regenerating Rat Liver," The Journal of Biological Chemistry, vol. 260, No. 1, Jan. 10, 1985, pp. 57-63.
Behrens, Nicolas and Eduardo Tabora, "Dolichol Intermediates in the Glycosylation of Proteins." Method in Enzymology, 50:402-435, 1977.
Hubbard, S. Catherine and Raymond J. Ivatt, "Synthesis and Processing of Asparagine-Linked Oligosaccharides," Ann. Rev. Biochem, 50:555-83, 1981.
Ronin, Catherine et al., "Enzymatic N-Glycosylation of Synthetic Asn-X-Thr Containing Peptides," FEBS Letters, vol. 96, No. 1, Dec. 1978, pp. 179-182.
Sharma, Chandra B. et al., "N-Glycosylation of Yeast Proteins," Eur. J. Biochem, 116, pp. 101-108 (1981).
Chen, Winston W. and William J. Lennarz, "Metabolism of Lipid-linked N-Acetylglucosamine Intermediates," The Journal of Biological Chemistry, vol. 252, No. 10, May 25, 1977, pp. 3473-3479.
Hendrickson, T. L.; Imperiali, B. "Metal Ion Dependence of Oligosaccharyl Transferase: Implications for Catalysis," Biochemistry 1995, 34, 9444.
Imperiali, B.; Rickert, K. W. "Conformational implications of asparagine-linked glycosylation," Proc. Natl. Acad. Sci. USA 1995, 92, 97.
Imperiali, B.; Spencer, J. R.; and Struthers, M. D. "Structural and Functional Characterization of a Constrained Asx-Turn Motif," J. Am. Chem. Soc. 1994, 116, 8424.
Imperiali, B; Shannon, K. L.; and Rickert, K. W. "Role of Peptide Conformation in Asparagine-Linked Glycosylation," J. Am Chem Soc. 1992, 114,8642.
Hendrickson, T. L.; Sepncer, J. R. Kato, M. et al. "Design and Evaluation of Potent Inhibitors of Asparagine-Linked Protein Glycosylation," J. Am Chem Soc. 1996, 118, 7636.
Hendrickson Tamara L.
Imperiali Barbara
Spencer Jeffrey R.
Borin Michael
Tsang Cecilia J.
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