Inhibitors of nucleoside metabolism

Details Inhibitors of nucleoside metabolism Inhibitors of nucleoside metabolism

1998-10-14

2000-05-23

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 221, 536 245, 536 253, 536 2613, 536 2671, 514 1, 514 44, C07H 1900, C07H 2102, C07H 2100, A01N 6100

Patent

active

060667222

ABSTRACT:
The present invention provides compounds having the formula: ##STR1## wherein A is CH or N; B is chosen from OH, NH.sub.2, NHR, H or halogen; D is chosen from OH, NH.sub.2, NHR, H, halogen or SCH.sub.3 ; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof; and compounds having the formula: ##STR2## wherein A, X, Y, Z and R are defined for compounds of formula (I) where first shown above; E is chosen from CO.sub.2 H or a corresponding salt form, CO.sub.2 R, CN, CONH.sub.2, CONHR or CONR.sub.2 ; and G is chosen from NH.sub.2, NHCOR, NHCONHR or NHCSNHR; or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester thereof, or a prodrug thereof.
The present invention also provides the use of the above compounds as pharmaceuticals, pharmaceutical compositions containing the compounds and processes for preparing the compounds.

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