Inhibitors of nonenzymatic cross-linking

Details Inhibitors of nonenzymatic cross-linking Inhibitors of nonenzymatic cross-linking

1990-10-30

1992-08-18

Willis, Jr., Prince

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514614, 424400, 424401, 426268, 426269, 426320, 426321, A01N 4106, A01N 4112, A61K 900, A23L 127

Patent

active

051400480

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises; an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents contain an active nitrogen-containing group, such as a hydrazine group. Particular agents comprise aminoguanidine derivatives. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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