Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1997-07-25
2000-02-15
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
562 8, 546 22, 548414, 549 6, 549218, 514277, 514415, 514438, 514461, A61K 3166, C07F 902
Patent
active
060253452
ABSTRACT:
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
REFERENCES:
patent: 4151172 (1979-04-01), Ondetti et al.
patent: 4168267 (1979-09-01), Petrillo, Jr.
patent: 4316896 (1982-02-01), Thorsett et al.
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4374131 (1983-02-01), Petrillo, Jr.
patent: 4444765 (1984-04-01), Karanewsky et al.
patent: 4448772 (1984-05-01), Karanewsky
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 4452791 (1984-06-01), Ryono et al.
patent: 4468519 (1984-08-01), Krapcho
patent: 4547324 (1985-10-01), Wong et al.
patent: 4555506 (1985-11-01), Karanewsky et al.
patent: 4560680 (1985-12-01), Ryono et al.
patent: 4560681 (1985-12-01), Karanewsky
patent: 4567166 (1986-01-01), Karanewsky et al.
patent: 4616005 (1986-10-01), Karanewsky et al.
patent: 4703043 (1987-10-01), Karanewsky et al.
patent: 4715994 (1987-12-01), Parsons et al.
patent: 4716155 (1987-12-01), Karanewsky et al.
patent: 4849525 (1989-07-01), Weller, III et al.
patent: 4885283 (1989-12-01), Broadhurst et al.
patent: 4906779 (1990-03-01), Weber et al.
patent: 4918064 (1990-04-01), Cordi et al.
patent: 4959493 (1990-09-01), Ohfume et al.
patent: 4962097 (1990-10-01), Parsons et al.
patent: 4988681 (1991-01-01), Ishikawa et al.
patent: 4994446 (1991-02-01), Sokolovsky et al.
patent: 5030732 (1991-07-01), Morita et al.
patent: 5041644 (1991-08-01), Morita et al.
patent: 5061806 (1991-10-01), Morita et al.
patent: 5093525 (1992-03-01), Weber et al.
patent: 5099063 (1992-03-01), Parsons et al.
patent: 5136080 (1992-08-01), Miller et al.
patent: 5143908 (1992-09-01), Parsons et al.
patent: 5145990 (1992-09-01), Parsons et al.
patent: 5147867 (1992-09-01), Parsons et al.
patent: 5162504 (1992-11-01), Horoszewicz
patent: 5190976 (1993-03-01), Weber et al.
patent: 5242915 (1993-09-01), Ueda et al.
patent: 5262568 (1993-11-01), Weber et al.
patent: 5326856 (1994-07-01), Coughlin et al.
patent: 5336689 (1994-08-01), Weber et al.
patent: 5449761 (1995-09-01), Belinka, Jr. et al.
patent: 5489525 (1996-02-01), Pastan
patent: 5495042 (1996-02-01), Belinka, Jr. et al.
patent: 5500420 (1996-03-01), Maiese
patent: 5508273 (1996-04-01), Beers et al.
patent: 5527885 (1996-06-01), Coughlin et al.
patent: 5538866 (1996-07-01), Israeli et al.
patent: 5538957 (1996-07-01), Tsaklakidis et al.
patent: 5672592 (1997-09-01), Jackson et al.
Vornov, James J., "Toxic NMDA-Receptor Activation Occurs During Recovery in a Tissue Culture Model of Ischemia," J. of Neurochemistry, (1995) 65:4, 1681-1691.
Slusher, Barbara S. et al., "Rat Brain N-Acetylated .alpha.-Linked Acidic Dipeptidase Activity," J. of Biological Chemistry, (1990) 265:34, 21297-21301.
Slusher, Barbara S. et al., "Immunocytochemical Localization of the N-Acetyl-Aspartyl-Glutamide (NAAG) Hydrolyzing Enzyme N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase)," J. of Comparative Neurology, (1992) 315, 217-229.
Slusher, Barbara S., "NAALADase: A Potential Regulator of Synaptic Glutamate," Biotech Update DuPont NEN, (1994) 9:2, 37-39.
Jackson, Paul F. et al., "Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated .alpha.-Linked Acidic Dipeptidase," J. of Medicinal Chemistry, (1995) 39:2, 619-622.
Carter, Ruth E. et al., "Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase," Proc. Nat. Acad. Sci. USA, (1996) 93, 749-753.
Heston, W.D.W., "Potential Uses of Prostate Specific Membrane Antigen (PMSA): a Neurocarboxypeptidase and Membrane Folate Hydrolase," Urologe [A], v. 35, pp. 400-407 (1996).
Hurn, P., "Gender-Linked Injury After Focal Cerebral Ischemia," Society for Neuroscience 1996 Abstract Form, (1996).
Bhardwaj, A., "Striatal Nitric Oxide (NO) Production is Enhanced In Focal Cerebral Ischemia: An In Vivo Microdialysis Study," Society for Neuroscience 1996 Abstract Form, (1996).
Stauch, Barbara L. et al., "The effects of N-acetylated alpha-linked acidic dipeptidase (NAALADase) inhibitors on [.sup.3 H] NAAG catabolism in vivo," Neuroscience Letters, (1989) 100, 295-300.
Meyerhoff, James L. et al., "Activity of a NAAG-hydrolizing enzyme in brain may affect seizure susceptibility in genetically epilepsy-prone rats," Molecular Neurobiology of Epilepsy, (1992) Chap. 16, 163-172.
Subasinghe, N. et al., "Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated .alpha.-linked acidic dipeptidase (NAALA dipeptidase)," J. Med. Chem, (1990) 33, 2734-2744.
Coyle, J. et al., "N-acetyl-aspartyl glutamate," Excitatory Amino Acids, (1991) 69-77.
Tsai, G. et al., "Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis," Brain Research, (1991) 556, 151-156.
Tsai, G. et al., "Changes of excitatiry neurotransmitter metabolism in schizophrenic brains," Salmon Lecturer of the New York Academy of Medicine (Dec. 2-3, 1993).
Rothstein, J. et al., "Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis," Anals of Neurologu, (1990) 28:1, 18-25.
Tsai, G. et al., "Immunocytochemical distribution of N-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways," J. of Chem. Neuroanatomy, (1993) 6, 277-292.
Koenig, M. et al., "N-acetyl-aspartyl-glutamate (NAAG) elicits rapid increase in intraneuronal Ca.sup.2+ in vitro," NeuroReports, (1994) 5, 1063-1068.
Woods, D. et al., "Gender-linked injury after focal ischemia," Soc. for Neuroscience 1996 Abstract Form, (1996).
Myerhoff, J. et al., "Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate," Brain Research, (1992) 593, 140-143.
Jackson Paul F.
Maclin Keith M.
Slusher Barbara S.
Tays Kevin L.
Aulakh Charanjit S.
Guilford Pharmaceuticals Inc.
Juneau Todd L.
Kight John
Nath Gary M.
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