Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1996-12-31
1998-08-18
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
562 8, 562 24, C07F 930, C07F 938, A61K 3166
Patent
active
057958777
ABSTRACT:
The present invention includes compounds, compositions, and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include phosphonate derivatives and mixtures thereof that inhibit NAALADase enzyme activity and their use for treating glutamate abnormalities such as created by global and focal ischemia and for treatment of prostate disease and prostate cancer by inhibition of NAALADase enzyme.
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Jackson Paul F.
Maclin Keith M.
Slusher Barbara S.
Tays Kevin L.
Guilford Pharmaceuticals Inc.
Juneau Todd L.
Nath Gary M.
Rotman Alan L.
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