Inhibitors of N-ethylmaleimide sensitive factor

Details Inhibitors of N-ethylmaleimide sensitive factor Inhibitors of N-ethylmaleimide sensitive factor

2011-03-22

2011-03-22

Salimi, Ali R. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

Reexamination Certificate

active

07910111

ABSTRACT:
Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptide to cross the cellular membrane (e.g. a domain from the TAT protein of HIV) and a domain that inhibits NSF (e.g. a domain of NSF). Administration of the fusion peptide promotes anticoagulation, attenuates thrombosis, and decreases heart attack severity.

REFERENCES:
patent: 5981192 (1999-11-01), Bandman et al.
patent: 2002/0037557 (2002-03-01), Jing et al.
Blanes-Mira et al, Society for Neuroscience Abstracts, 2001, vol. 27, No. 1, pp. 1017.
Whiteheart et al. “N-Ethylmaleimide-sensitive Fusion Attachment proteins (SNAPS) Bind to aMulti-SNAP Receptor in Golgi Membranes” The Journal of Biological Chemistry, vol. 267. No. 17; Jun. 15, 1992, pp. 12239-12243.

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