Inhibitors of microsomal triglyceride transfer protein and metho

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514290, 514318, 514323, 546111, 546141, 546194, 546200, A61K 3147, A61K 31445, C07D22116, C07D21722

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active

060340983

ABSTRACT:
Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.

REFERENCES:
patent: 3910931 (1975-10-01), Cavalla et al.
patent: 4000287 (1976-12-01), Werner
patent: 4029795 (1977-06-01), Eichenberger et al.
patent: 4053615 (1977-10-01), Boyle et al.
patent: 4289781 (1981-09-01), Bengtsson et al.
patent: 4291042 (1981-09-01), Ward
patent: 4367232 (1983-01-01), Boix-Igleasias et al.
patent: 4576940 (1986-03-01), Tahara et al.
patent: 4581355 (1986-04-01), Tahara et al.
patent: 4607042 (1986-08-01), Pierce
patent: 4826975 (1989-05-01), Picciola et al.
patent: 5032598 (1991-07-01), Baldwin et al.
patent: 5130333 (1992-07-01), Pan et al.
patent: 5189045 (1993-02-01), Peglion et al.
patent: 5215989 (1993-06-01), Baldwin et al.
patent: 5527801 (1996-06-01), Masuda et al.
Bulleid & Freedman, Nature 335, 649-651 (1988). "Defective co-trans-lational formation of disulphide bonds in protein disulphideisomerase-deficient microsomes".
Koivu et al., J. Biol. Chem. 262, 6447-6449 (1987). "A Single Polypep-tide Acts Both as the .beta. Subunit of Prolyl 4-Hydroxylase and as a Protein Disulfide-Isomerase*".
Kane & Havel in the Metabolic Basis of Inherited Disease, Sixth Edition, 1139-1164 (1989). "Disorders of the Biogenesis and Secretion of Lipoproteins Containing The B Apolipoproteins".
Schaefer et al., Clin. Chem. 34, B9-B12 (1988). "Genetics and Abnormaities in Metabolism of Lipoproteins".
Drayna et al., Nature 327, 632-634 (1987). "Cloning and sequencing or human cholesteryl ester transfer protein cDNA".
Pihlajaniemi et al., EMBO J. 6, 643-649 (1987). "Molecular cloning of the .beta.-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene".
Yamaguchi et al., Biochem. Biophys. Res. Comm. 146, 1483-1492 (1987). "Sequence of Membrane-Associated Thyroid Hormone Binding Protein From Bovine Liver: Its Identity with Protein Disulphide Isomerase".
Edman et al., Nature 317, 267-270 (1985). Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin.
Kao et al., Connective Tissue Research 18, 157-174 (1988). "Isolation of cDNA Clones and Genomic DNA Clones of .beta.-Subunit of Chicken Prolyl 4-Hydroxylase*".
Wetterau, J. et al., Biochem 30, 9728-9735 (1991). "Protein Disulfide Isomerase Appears Necessary To Maintain the Catalytically Active Structure of the Microsomal Triglyceride Transfer Protein".
Morton, R.E. et al., J. Biol. Chem. 256, 1992-1995 (1981). "A Plasma Inhibitor of Triglyceride and Chloesteryl Ester Transfer Activities".
Wetterau, J. et al., Biochem: 30, 4406-4412 (1991): "Structural Properties of the Microsomal Triglyceride-Transfer Protein Complex".
Wetterau, J. et al., J. Biol. Chem. 265, 9800-9807 (1990). "Protein Disulfide Isomerase Is a Component of the Microsomal Triglyceride Transfer Protein Complex".
Wetterau, J. and Zilversmit, D.B., Chem. and Phys. of Lipids 38, 205-222 (1985). "Purification and Characterization of Microsomal Triglyceride and Cholesteryl Ester Transfer Protein From Bovine Liver Microsomes".
Wetterau, J. and Zilversmit, D.B., Biochimica et Biophysica Acta 875, 610-617 (1986). "Localization of intracellular triacylglycerol and cholesteryl ester transfer activity in rat tissues".
Wetterau, J. and Zilversmit, D.B., J. Biol. Chem. 259, 10863-10866 (1984). "A Triglyceride and Cholesteryl Ester Transfer Protein Associated with Liver Microsomes".
Wetterau,. J., Grant Application entitled: "Intracellular Triglyceride Transport and Metabolism", 1987.
Presentation Materials, Aspen Bile Acid/Cholesterol Conference, Aug. 15, 1992.
Wetterau, J. R., et al., Science, vol. 258, 999-1001, Nov. 6, 1992, "Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia".
Archibald, J. L., et al., Journal of Medicinal Chemistry, vol. 14, No. 11, pp. 1054-1059, 1971.
Cortizo, L. et al., J. Med. Chem., 34, pp. 2242-2247, 1991.
Hall, I. H. et al., Pharmaceutical Research, vol. 9, No. 10, pp. 1324-1329, 1992.
Hall, I. H., et al., Pharmacological Research Communications, vol. 19, No. 12, pp. 839-858, 1987.
Murthy et al., Eur. J. Med. Chem. --Chim. Ther., vol. 20, No. 6, pp. 547-550, 1985.
Derwent Abstract No. 93-117225/14, 1993.

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