Inhibitors of metazoan parasite proteases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai

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514646, 514676, A61K 3112, A61K 31135

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active

057391700

ABSTRACT:
Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I

REFERENCES:
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Chemical Abstracts, "Biofioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by intraerythrocytic parasite", 110(11)18, column 2, abstract No. 87987p, Biochem. Parmacol., 37(22):4269-76, 1989.
Proceedings of the National Academy of Sciences, vol. 90, Issued Apr. 1993, Ring et al "Structural-Based Inhibitor Design by Using Protein Models for the Development of Antiparasitic Agents" pp. 3583-3587.
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Chemical Abstracts, vol. 113, No. 22, Issued 1989, Kino and Kato, "Hair Dye Taining Water-Soluble Dyes, Carbon Black, and Nonionic Surfactants," See Abstract No. 197653, JP 01242518.
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Rosenthal et al. The American Society for Clinical Investigation, Inc. "Antimalarial Effectis of Peptide Inhibitors of Plasmodium falciparum Cysteine Proteinase" vol. 88, Nov. 1991, 1467-1472.

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