Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-06-18
1999-11-23
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544385, 544231, 544349, 544350, 514249, A61K 31495, C07D24108
Patent
active
059901128
ABSTRACT:
Novel inhibitors of metalloproteases are disclosed. Such compounds are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, such as rheumatoid arthritis.
REFERENCES:
patent: 4609667 (1986-09-01), Clark et al.
patent: 4940709 (1990-07-01), Shimazaki et al.
patent: 5728830 (1998-03-01), Kanda et al.
patent: 5736539 (1998-04-01), Graham et al.
patent: 5817751 (1998-10-01), Szardenings et al.
Bernstein, et al., "Preparation of a Diketopiperazine Analog of Leukotriene D.sub.4 (LTD.sub.4)", Tetrahedron Letters, vol. 26, No. 16, pp. 1951-1954, 1985.
Dudman, et al., "Homocysteine Thiolactone and Experimental Homocysteinemia", Biochemical Medicine, (27), pp. 244-253 (1982).
Rossbach, et al., Abstract, for Physiol. -Chem. Inst., University Tuebingen, Tuebingen, Germany, Z. Naturforsch. B (1971), 26(11), pp. 1144-1151.
Schneider, et al., "Kinetik der Reaktion von Imidazol-SH-Verbindungen mit N-Athyl-maleinimid", Hoppe-Seyler's Z. Physiol. Chem, pp. 1521-1530, Dec. 1969.
Richter, et al., "Penicillamine: An Extractable Chiral Auxiliary Providing Excellent Stereocontrol", Tetrahedron: Asymmetry, vol. 7, No. 2, pp. 427-434 (1996).
Chemical Abstracts, vol. 117, No. 33, 1992, Abstract No. 0275b, Nachev: Synthesis of N-Polyfunctional Substituted L-Phenylalanine, p. 849, col. 1, XP002040920.
Birkedal-Hansen et al, Critical Reviews in Oral Biology and Medicine, 4 (2), pp. 197-250 (1993).
Vincenti et al, Arthritis & Rheumatism, 37, p. 1115-1126 (1994).
Beyermann et al, J. Org. Chem. 55, p. 721-728 (1990).
Campbell David
Look Gary C.
Patel Dinesh V.
Szardenings Anna Katrin
Affymax Technologies N.V.
Bernhardt Emily
Stevens Lauren L.
Swiss Gerald F.
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