Inhibitors of melanocyte tyrosinase as topical skin lighteners

Details Inhibitors of melanocyte tyrosinase as topical skin lighteners Inhibitors of melanocyte tyrosinase as topical skin lighteners

2008-09-08

2010-12-28

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

C514S183000

Reexamination Certificate

active

07858105

ABSTRACT:
Methods and formulations are provided to reduce pigmentation in skin, using an array of compounds selected from benzimidazoles, phenylthioureas, phenylthiols, phenylamines, bi- and multicyclic phenols, thiopheneamines, and benzothiamides. The compounds preferably inhibit pigment synthesis in melanocytes through the tyrosinase pathway. The methods can be used for lightening skin, and for treating uneven skin complexions which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically.

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