Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2010-09-10
2011-11-22
Saeed, Kamal (Department: 1622)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S266100, C514S311000, C544S235000, C544S283000, C546S171000
Reexamination Certificate
active
08063049
ABSTRACT:
This invention concerns to N-(2-aylamino)aryl sulfonamides, which are inhibitors of MEK, methods of using such compounds in the treatment of hyperproliferative diseases, and to pharmaceutical compositions containing such compounds.
REFERENCES:
patent: 5861510 (1999-01-01), Piscopio et al.
patent: 5863949 (1999-01-01), Robinson et al.
patent: 0606046 (1994-07-01), None
patent: 0679641 (1995-11-01), None
patent: 0780386 (1997-06-01), None
patent: 97304971.1 (1997-07-01), None
patent: 99302232.1 (1999-03-01), None
patent: 0931788 (1999-07-01), None
patent: 99308617.2 (1999-10-01), None
patent: WO 90-05719 (1990-05-01), None
patent: WO 96-27583 (1996-03-01), None
patent: WO 96-33172 (1996-10-01), None
patent: WO 98-03516 (1998-01-01), None
patent: WO 98-07697 (1998-02-01), None
patent: WO 98-30566 (1998-07-01), None
patent: WO 98-33768 (1998-08-01), None
patent: WO 98-34915 (1998-08-01), None
patent: WO 98-34918 (1998-08-01), None
patent: WO 99-07675 (1999-02-01), None
patent: WO 99-29667 (1999-06-01), None
patent: WO 99-32889 (1999-10-01), None
patent: WO 99-52910 (1999-10-01), None
patent: WO 2000-74681 (2000-12-01), None
patent: WO 2004-031174 (2004-04-01), None
patent: WO 2004-083167 (2004-09-01), None
patent: WO 2005-051302 (2005-06-01), None
patent: WO 2005-051906 (2005-06-01), None
U.S. Appl. No. 60/148,464, filed Aug. 12, 1999.
Ahn et al., “Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase,” Science 265;966-970 (1994).
Li, C. et al., “Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives,” J. Med. Chem. 38:4897-4905 (1995).
PCT/US08/051518 Search Report dated May 21, 2008.
Fleischer et al., “Improved oral drug delivery: solubility limitations overcome by the use of prodrugs,” Adv. Drug Del. Rev. 19:115-130 (1996).
Robinson et al., “Discovery of the Hemifumarate and (α-L-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group,” J. Med. Chem. 39:10-18 (1996).
Vippagunta et al., Crystalline solids, 2001, Advanced Drug Delivery Reviews, 48, pp. 3 and 18.
Wolff et al., Burger's Medicinal Chemistry and Drug Discovery, 1994, Wiley-Interscience, Fifth Edition, vol. I: Principles and Practice, pp. 975-977.
Kwon et al., Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists, 2001, http://www.myilibrary.com/Browse/open.asp?ID=4284&loc=1, Retrieved from the Internet Jun. 16, 2008, p. 213.
Metabolomics [online], Retrieved from the Internet Jun. 16, 2008, URL: http://www.en.wikipedia.org/wiki/Metabolomics, p. 1.
Lala et al., Role of nitric oxide in tumor progression: Lessons from experimental tumors, Cancer and Metastasis Reviews (1998), 17, 91-106.
Golub et al., Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring, Science (1999), vol. 286, 531-537.
Hong Zhi
Koh Yung-hyo
Maderna Andreas
Vernier Jean-Michel
Ardea Biosciences Inc.
Bianchi Kristin
Millen White Zelano & Branigan P.C.
Saeed Kamal
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