Inhibitors of MAdCAM-1-mediated interactions and methods of use

Details Inhibitors of MAdCAM-1-mediated interactions and methods of use Inhibitors of MAdCAM-1-mediated interactions and methods of use

1996-01-04

2000-03-14

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530300, 530331, A61K 3800, A61K 3806, A61K 3807

Patent

active

060373245

ABSTRACT:
The present invention provides novel compounds comprising peptide sequences which mimic the conserved amino acid motif LDTSL and which have groups bonded to the N- and C-termini. Also provided are methods of inhibiting the interaction of a cell bearing a ligand of MAdCAM-1, such as human .alpha.4.beta.7, with MAdCAM-1 or a portion thereof (e.g., the extracellular domain), comprising contacting the cell with a compound of the present invention.

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