Inhibitors of macrophage migration inhibitory factor and...

Details Inhibitors of macrophage migration inhibitory factor and... Inhibitors of macrophage migration inhibitory factor and...

2007-12-25

2007-12-25

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S235200

Reexamination Certificate

active

11592364

ABSTRACT:
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures:including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

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