Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-02-25
2000-07-04
Minnifield, Nita
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
514443, 514 25, 514 26, 514 27, 514 28, 514 29, 514 30, 514 31, 435184, 435 72, 435 71, 530351, 530396, 530399, G01N 3353, A01N 4304, A01N 4500, C12N 999, C07K 100
Patent
active
060837063
ABSTRACT:
Methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a compound that inhibits the binding of the leaderless protein and a transport molecule are provided. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL-1.beta., CNTF and HIV-tat. These methods are useful in treatment of various conditions, including tumors and diabetes.
REFERENCES:
patent: 4975467 (1990-12-01), Ku et al.
patent: 5545623 (1996-08-01), Matsumori
patent: 5891855 (1999-04-01), Florkiewicz
Barinaga, "A Shared Strategy for Virulence," Science 272: 1261-1263, 1996.
Bost and Berlin, "A new genetic selection identifies essential residues in SecG, a component of the Escherichia coli protein export machinery," The EMBO Journal 14(18): 4412-4421, 1995.
DeTomaso et al., "The .alpha. and .beta. Subunits of the Na, K-ATPase Can Assemble at the Plasma Membrane into Functional Enzyme," The Journal of Cell Biology 127: 55-69, 1994.
Florkiewicz et al., "Cardenolides inhibit FGF-2 protein export: A novel regulatory function for Na+, K+-ATPase," FASEB Journal 11(9): No. 1222, p. A1066, 1997.
Florkiewicz et al., "Quantitative Export of FGF-2 Occurs Through and Alternative, Energy-Dependent, Non-ER/Golgi Pathway," Journal of Cellular Physiology 162:388-399, 1995.
Florkiewicz et al., "Regulation Of FGF-2 Export By Cardenolides," Molecular Biology Of The Cell 7(Suppl.):No. 1080, p. 186a, 1996.
Florkiewicz et al., "The Inhibition of Fibroblast Growth Factor-2 Export by Cardenolides Implies a Novel Function for the Catalytic Subunit of Na.sup.+, K.sup.+ -ATPase," The Journal of Biological Chemistry 273(1):544-551, 1998.
Goldstein, "HIV 1 Tat protein as a potential AIDS vaccine," Nature Medicine 1(9):960-964, 1996.
Hamon et al., "Interleukin-1.beta. Secretion Is Impaired by Inhibitors of the Atp Binding Cassette Transporter, ABC1," Blood 90(8):2911-2915, 1997.
Jackson et al., "The Release of Fibroblast Growth Factor-1 from NIH 3T3 Cells in Response to Temperature Involves the Function of Cysteine Residues," The Journal of Biological Chemistry 270(1):33-36, 1995.
Jarvis et al., "Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation," Proc. Natl. Acad. Sci. USA 92: 7996-8000, 1995.
Jerse et al., "A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells," Proc. Natl. Acad. Sci. USA 87: 7839-7843, 1990.
Kaelin Jr. et al., "Identification of Cellular Proteins That Can Interact Specifically with the T/E1A-Binding Region of the Retinoblastoma Gene Product," Cell 64:521-532, 1991.
Kenny and Finlay, "Protein secretion by enteropathogenic Escerichia coli is essential for transducing signals to epthelial cells," Proc. Natl. Acad. Sci. USA 92: 7991-7995, 1995.
Kent et al., "Ouabain Resistance Conferred by Expression of the cDNA for a Murine Na.sup.+, K.sup.+ -ATPase .alpha. Subunit," Science 237:901-903, 1987.
Levenson, "Isoforms of the Na, K-ATPase: Family Members in Search of Foundation," Rev. Physiol. Biochem. Pharmacol. 123: 1-45, 1994.
Lewis, "Multidrug resistance pumps in bacteria: variations on a theme," TIBS 19: 119-124, 1994.
McDaniel et al., "A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens," Proc. Natl. Acad. Sci. USA 92: 1664-1668, 1995.
Mignatti et al., "Basic Fibroblast Growth Factor, a Protein Devoid of Secretory Signal Sequence, Is Released by Cells via a Pathway Independent of the Endoplasmic Reticulum-Golgi Complex," Journal Of Cellular Physiology 151: 81-93, 1992.
Neyfakh et al., "Efflux-mediated multidrug resistance in Bacillus subtilis: Similarities and dissimilarities with the mammalian system," Proc. Natl. Acad. Sci. USA 88: 4781-4785, 1991.
Rubartelli et al., "A novel secretory pathway for interleukin-1.beta., a protein lacking a signal sequence," The EMBO Journal 9(5): 1503-1510, 1990.
Rubartelli et al., "Secretion of Thioredoxin by Normal and Neoplastic Cells through a Leaderless Secretory Pathway," The Journal Of Biological Chemistry 267(34):24161-24164, 1992.
Russel, "Phage Assembly: A Paradigm for Bacterial Virulence Factor Export," Science 265: 612-614, 1994.
Salmond and Reeves, "Membrane traffic wardens and protein secretion in Gram-negative bacteria," TIBS 18: pp. 7-12, 1993.
Harlow etal, Antibodies, A laboratory manual 421-466 and 511-551, 1988.
Nilsson et al, Fusion proteins in biotechnology and structural biology, Current opinion in structural biology, vol. 2, pp. 569-575, 1992.
Baird Andrew
Florkiewicz Robert Z.
Baskar Padma
Ciblex Corporation
Minnifield Nita
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