Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1997-03-28
1999-10-26
Tsang, Cecilia
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
530331, 514 17, 514 18, A61K 3807
Patent
active
059731117
ABSTRACT:
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1.beta. converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
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Bemis Guy W.
Golec Julian M. C.
Lauffer David J.
Livingston David J.
Mullican Michael D.
Dixon Lisa A.
Haley, Jr. James F.
Lukton David
Tsang Cecilia
Vertex Pharmaceuticals Inc.
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