Inhibitors of interleukin-1.beta. converting enzyme

Details Inhibitors of interleukin-1.beta. converting enzyme Inhibitors of interleukin-1.beta. converting enzyme

1995-05-25

1998-12-08

Tsang, Cecilia J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

540 1, 540450, 540470, 540476, 540486, 540500, 540519, 540553, 544 1, 544179, 544180, 544224, 544355, 544386, 544383, 546112, 546192, 546162, 546146, 546245, 546268, 548183, 548200, 5483044, 5483335, 548494, 548504, 548482, 548571, C07D22500, C07D48700, C07D29500, C07D23700

Patent

active

058471359

ABSTRACT:
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1.beta. converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.

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