Inhibitors of IMPDH enzyme

Details Inhibitors of IMPDH enzyme Inhibitors of IMPDH enzyme

2011-08-02

2011-08-02

Kumar, Shailendra (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S374000, C514S468000, C514S522000, C514S535000, C514S580000, C514S617000

Reexamination Certificate

active

07989498

ABSTRACT:
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

REFERENCES:
patent: 1935554 (1933-11-01), Grether et al.
patent: 2025116 (1935-12-01), Lubs et al.
patent: 2965575 (1960-12-01), Beaver et al.
patent: 3064049 (1962-11-01), Cox et al.
patent: 3573051 (1971-03-01), Gray
patent: 3973038 (1976-08-01), Umezawa et al.
patent: 4028394 (1977-06-01), Karsten et al.
patent: 4242260 (1980-12-01), Sasaki et al.
patent: 5070096 (1991-12-01), Mohrs et al.
patent: 5093340 (1992-03-01), Mohrs et al.
patent: 5380879 (1995-01-01), Sjogren
patent: 5446010 (1995-08-01), Toyofuku et al.
patent: 5712298 (1998-01-01), Amschler
patent: 5721246 (1998-02-01), Yoshino et al.
patent: 6071968 (2000-06-01), Nishino et al.
patent: 6653309 (2003-11-01), Saunders et al.
patent: 1041502 (1978-10-01), None
patent: 1206964 (1986-07-01), None
patent: 332480 (1958-09-01), None
patent: 838 290 (1950-05-01), None
patent: 0051819 (1985-02-01), None
patent: 0211568 (1989-10-01), None
patent: 0221346 (1991-01-01), None
patent: 0279633 (1993-04-01), None
patent: 0610653 (1997-04-01), None
patent: 0673937 (2003-11-01), None
patent: 1584606 (1968-07-01), None
patent: 1459142 (1976-12-01), None
patent: 49-102693 (1974-09-01), None
patent: 49-127939 (1974-12-01), None
patent: 57-122039 (1982-07-01), None
patent: 62-029562 (1987-02-01), None
patent: 62-081359 (1987-04-01), None
patent: 63-093765 (1988-04-01), None
patent: 63-222152 (1988-09-01), None
patent: 06-199047 (1994-07-01), None
patent: 06-297860 (1994-10-01), None
patent: 07-165708 (1995-06-01), None
patent: 08-143525 (1996-06-01), None
patent: 08-512041 (1996-12-01), None
patent: 09-157236 (1997-06-01), None
patent: WO 97/40028 (1997-10-01), None
patent: WO 99/55663 (1999-11-01), None
Buu-Hoi et al, Bull. de la Soc. Chim. de France(1947), 128-36.
Carter et al., Chemotherapy of Cancer, second edition, John Wiley & Sons, N.Y., N.Y., 1981, pp. 362-365.
Barr et al., “Indoaniline dyes”,Chemical Abstracts, (1961) 55:24.
Boit, Hans-G.: “Beilsteins Handbuch der Organischen Chemie, 4thEd. Suppl. III vol. 13” 1973, Springer Verlag, Berlin, Heidelberg, New York XP002111106 p. 837, para. 4; p. 838, para. 2; p. 2155, para. 3.
Hochuli et al., “Printing of nontextile sheets”,Chemical Abstracts, (1959) 53:15.
Kekre et al., “Syntheses and biological activity of 1,3-na-phthoxazine-2,4-diones”, 123834nChemical Abstracts, (1976) 85:17.
Kishimoto et al., “Synthesis of anilide derivatives of 1-hydroxy-2=naphthoic acid”,Chemical Abstracts, (1988) 108:5.
Luckenbach, Reiner: “Beilsteins Handbuch der Organischen Chemie, 4thEd. Suppl. II vol. 13” 1985, Springer Verlag, Berlin, Heidelberg, New York XP002111107 p. 1717, para. 1,2.
Mullink et al., “Combined immuno- and non-radioactive hybridocytochemistry on cells and tissue sections: influence of fixation, enzyme pretreatment, and choice of chromogen on detection of antigen and DNA sequences” 228120qChemical Abstracts, (1989) 110:25, p. 317.
Nishino et al., “Azo dyes derived from catechol”,Chemical Abstracts, (1959) 53:12.
Patani et al., “Bioisosterism: A Rational Approach in Drug Design”,Chem. Rev., 1996 96:3147-76.
Richter, Friedrich: “Beilsteins Handbuch der Organischen Chemie, 4thEd. Suppl. II vol. 13” 1950, Springer Verlag, Berlin, Göttingen, Heidelberg (DE) XP002111105 pg. 181, para. 6.
Sebe et al., “Organic pigments—AS-RS napthol derivatives”,Chemical Abstracts, (1989) 110:24, p. 103.
Solomons et al.,Anti-Cancer Drugs Des. (1997) 12 (98):635-647.
Webber et al., “A quantitative cytochemical assay for osteoclast acid phosphatase activity in fetal rat calvaria”, 110:3327nChemical Abstracts, (1989) 110:1, p. 309.
Allay et al., “Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors,”Blood, 90(9):3546-3554 (1997).
Cechinel-Filho et al., “Synthesis of xanthoxyline derivatives with antinociceptive and antioedematogenic activities,”European Journal of Medicinal Chemistry, 31(10):833-839 (1996).
Chen et al., “Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions,”Journal of Medicinal Chemistry, 37(6):845-859 (1994).
Chio et al., “Identification of a class of sulfonamides highly active against dihydropteroate synthase formToxoplasma gondii, Pneumocystis carinii, andMycobacterium avium,” Antimicrobial Agents and Chemotherapy, 40(3):727-733 (1996).
Cushman et al., “Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization,”Journal of Medicinal Chemistry, 34(8):2579-2588 (1991).
Hong et al., “Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs,”Antimicrobial Agents and Chemotherapy, 39(8):1756-1763 (1995).
Linfield et al., “Antibacterially active substituted anilides of carboxylic and sulfonic acids,”Journal of Medicinal Chemistry, 26(12):1741-1746 (1983).
Patakoot et al., “Preparation of some aryla of o, m and p —cresotic acids,”Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine Section A, 25(40):13-14 (1957).
Ramana et al., “Synthesis of 2-substituted benzoxazoles and benzimidazoles based on mass spectralorthointeractions”Journal of the Chemical Society, Perkin Transactions 2: (7):1497-501 (1995).
Grammaticakis, “No. 165.—Contribution to the study of the absorption in the middle ultraviolet range and the visible range of N-aroyl-arylamines. III.—o-, m-, p- methoxybenzoylalkoylamines and o-, m-, p- methoxybenzoylarylamines,”Bulletin de la Societe Chimique de France, 5:924-935 (1964) (English Language Abstract Attached).
Weuffen et al., “Investigation of 2-Hydroxythiobenzamides and 2- Hydroxythiobenzanilides. 4th Communication: Preliminary Investigations to Determine the Anthelminthic Efficacy of the Substances,”Pharmazie, 23(6):308-310 (1968) (English Language Summary Attached).

Affiliated with

Also associated with

Rating

Inhibitors of IMPDH enzyme does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of IMPDH enzyme, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of IMPDH enzyme will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2677336