Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-04-23
1998-09-15
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548236, A61K 3142, C07D26334, C07D41300
Patent
active
058078762
ABSTRACT:
The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as agents for immunosuppression. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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G.M. Makara et al. "Nuclear Magnetic Resonance and Molecular Modeling Study on Mycophenolic Acid: Implications for Binding to Inosine Monophosphate Dehydrogenase", J. Med. Chem. 39, pp. 1236-1242 (Mar., 1996).
C. Montero et al., "Demonstrations of Induction of Erythocyte Inosine Monophosphate Dehydrogenase Acitivity in Ribavirin-Treated Patients Using a High Performance Liquid Chromatography Linked Method", Clinica Chimica Acta, 238, pp. 169-178 (Aug., 1995).
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Armistead David M.
Badia Michael C.
Bemis Guy W.
Bethiel Randy S.
Frank Catharine A.
Govindaswamy N.
Haley, Jr. James F.
Kifle Bruck
Shah Mukund J.
Vertex Pharmaceuticals Incorporated
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