Inhibitors of hydroxyphenylpyruvate dioxygenase and an assay for

Details Inhibitors of hydroxyphenylpyruvate dioxygenase and an assay for Inhibitors of hydroxyphenylpyruvate dioxygenase and an assay for

1995-01-06

1998-12-01

Lankford, Jr., Leon B.

Plant protecting and regulating compositions

Plant growth regulating compositions

Organic active compound containing

435184, 514684, 549349, 568333, A01N 3500

Patent

active

058438696

ABSTRACT:
There are described a method for enriching the anabolic p-hydroxyphenylpyruvate dioxygenases from plant tissues and a method by means of which the enzymatic activity of the enzyme can be measured in a simple manner without complete purification of the enzyme being necessary. The invention furthermore describes an assay system for identifying inhibitors of p-hydroxyphenylpyruvate dioxygenase from plants, in which an enriched HPPD from plants is incubated with a test substrate to be examined and the enzymatic activity of the enzyme is determined in comparison with the activity of the uninhibited enzyme. The invention furthermore describes the novel herbicidal active substances of the formula (I) ##STR1## which were found using the assay method according to the invention.

REFERENCES:
patent: 3954875 (1976-05-01), Swithenbank et al.
patent: 3988300 (1976-10-01), Cross
patent: 4026697 (1977-05-01), Cross
patent: 4588433 (1986-05-01), Schmitt et al.
patent: 4872902 (1989-10-01), Brunner
patent: 4910327 (1990-03-01), Doehner, Jr.
patent: 4938790 (1990-07-01), Smith et al.
patent: 4979978 (1990-12-01), Renga et al.
patent: 4999448 (1991-03-01), Smith et al.
patent: 5012017 (1991-04-01), Orvik et al.
patent: 5108486 (1992-04-01), Kondo et al.
Chemical Abstracts, vol. 92, No. 3, Jan. 21, 1980, Abstract No. 17781c by E. Maruyama entitled "Homogentisic acid formation by p-hydroxphenylpyruvate hydroxylase in bamboo shoots".
Planta, vol. 155, 1982, pp. 511-515 by Fiedler et al. entitled "The formation of homogentisate in the biosynthesis of tocopherol and plastoquinone in spinach chloroplasts".
Febs Letters, vol. 104, No. 2, Aug., 1979, pp. 332-334 by Loffelhardt et al. entitled "Conversion of 4-hydroxyphenylpyruvic acid into homogentisic acid at the thylakoid membrane of Lemna gibba".
Febs Letters, vol. 318, No. 2, Mar. 1993, pp. 162-166 by Schultz et al. entitled "SC-0051, a 2-benzoyl-cyclohexane-1,3-dione bleaching herbicide, is a potent inhibitor of the enzyme p-hyroxyphenylpyruvate dioxygenase".
Muray P. Deutscher, 1990, Academic Press Inc. entitled "Guide to protein purification".
Chemical Abstracts, vol. 77, No. 25, Dec. 18, 172, Abstract No. 161443b, by J.H. Fellman et al. entitled "Assay, properties, and tissue distribution of p-hydroxyphenylpyruvate hydroxylase".

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