Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfur containing
Patent
1995-06-05
1998-07-28
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Sulfur containing
504348, C07C31714
Patent
active
057865132
ABSTRACT:
There are described a method for enriching the anabolic p-hydroxyphenylpyruvate dioxygenases from plant tissues and a method by means of which the enzymatic activity of the enzyme can be measured in a simple manner without complete purification of the enzyme being necessary.
The invention furthermore describes an assay system for identifying inhibitors of p-hydroxyphenylpyruvate dioxygenase from plants, in which an enriched HPPD from plants is incubated with a test substrate to be examined and the enzymatic activity of the enzyme is determined in comparison with the activity of the uninhibited enzyme.
The invention furthermore describes the novel herbicidal active substances of the formula (I) ##STR1## which were found using the assay method according to the invention.
REFERENCES:
patent: 3954875 (1976-05-01), Switherbank et al.
patent: 3988300 (1976-10-01), Cross
patent: 4026697 (1977-05-01), Cross
patent: 4910327 (1990-03-01), Doehner, Jr.
patent: 4938790 (1990-07-01), Smith et al.
patent: 4979978 (1990-12-01), Renga et al.
patent: 4999448 (1991-03-01), Smith et al.
patent: 5012017 (1991-04-01), Orvik et al.
patent: 5108486 (1992-04-01), Kondo et al.
Methods in Enzymology, vol. 142, "4-Hydroxyphenylpyruvate Dioxygenase from Human Liver" by Lindstedt et al., pp. 139-141 (1987).
Methods in Enzymology, vol. 142, "4-Hydroxyphenylpyruvate Dioxygenase from Pseudomonas" by Lindstedt et al., pp. 143-148 (1987).
Elsevier/North-Holland Biomedical Press, FEBS Letters, vol. 104, No. 2, "Conversion of 4-Hydroxyphenylpyruvic Acid into Homogentisic Acid at the Thylakoid Membrane", by Lofelhardt et al., pp. 332-334, Aug., 1979.
Clinical Chimica Acta, vol. 34, "Radiochemical Assays for p-Hydrophenylpryuvate Hydroxylase Activity in Human Liver", by Bengt Lindblad, pp. 113-121 (1971).
Planta 155, "The Formation of Homogentisate in the Biosynthesis of Tocopherol and Plastoquinone in Spinach Chroloplasts" by Fiedler et al., pp. 511-515 (1982).
Grompe M et al., Nat. Genet. 10(4):453-60 (1995).
English Translation of Above JP Patents.
Geist Gary
Hoechst Aktiengesellschaft
Vollano Jean F.
LandOfFree
Inhibitors of hydroxyphenylpyruvate dioxygenase and an assay for does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of hydroxyphenylpyruvate dioxygenase and an assay for, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of hydroxyphenylpyruvate dioxygenase and an assay for will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-24841