Inhibitors of human immunodeficiency virus

Details Inhibitors of human immunodeficiency virus Inhibitors of human immunodeficiency virus

1993-09-28

1996-06-04

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 911, 4351721, C12N 1511, C12Q 168

Patent

active

055233899

ABSTRACT:
The phosphorothioate oligonucleotide T.sub.2 G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible 8-nucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosinequartet (G-quartet) structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The G-quartet structure binds to the HIV envelope protein gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell infection.

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