Inhibitors of HIV reverse transcriptase

Details Inhibitors of HIV reverse transcriptase Inhibitors of HIV reverse transcriptase

1995-06-07

1996-06-18

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548492, C07D20930, A61K 3140

Patent

active

055278191

ABSTRACT:
Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

REFERENCES:
patent: 4255442 (1981-03-01), Steinman et al.
patent: 4873259 (1989-10-01), Summers, Jr. et al.
patent: 5124327 (1992-06-01), Greenlee et al.
Savena, et al., J. Medicinal Chemistry, vol. 12, pp. 1120-1122 (1969).
Uhlendorf, et al., Chemical Abstracts, vol. 110, No. 25, Abstract No. 231432y (1989).
Chemical Abstracts, CA 117(21):212489a, 1992.
Inaba et al., Chem. Pharm. Bull., 24, 1076-1082 (1976).
Atkinson et al., Synthesis, 480-481 (Jun. 1988).
Nagarathnam et al., Synthesis, No. 11, 926-927 (Nov. 1982).
Mohan et al., Synthesis, No. 2, 188-190 (Feb. 1985).
Vedachalam, M., Tet. Letters, 24, 3531-3532 (1983).
Nagarathnam et al., Synthesis, No. 2, pp. 156-157 (Feb. 1983).
Selvakumaren et al., India J. of Chem., 24B, 692 (1985).
Ratner et al., Nature, 313, 277 (1985).
Toh et al., EMBO J., 4, 1267 (1985).
Power et al., Science, 231, 1567 (1986).
Pearl et al., Nature, 329 351 (1987).
Shvedov, V. I., et al., Chemical Abstracts, vol. 72, pp. 313-314, AB#12471D, (1970).
Dave, V., Chemical Abstracts, vol. 85, p. 374, AB#32754V, (1976).
Tomita, K., et al., Chemical Abstracts, vol. 87, p. 705, AB#135057R, (1977).
Banerji, A. et al., Chemical Abstracts, vol. 90, p. 575, AB#6272V, (1979).
Gairns, R. S., et al., Chemical Abstracts, vol. 106, p. 616, AB#49926C, (1987).
Atkinson, J. G., et al., Chemical Abstracts, vol. 109, p. 710, AB#149279Z, (1988).
Wojciechowski, K. et al., Chemical Abstracts, vol. 106, p. 618, AB#119608B, (1987).
Lewis, M. G. et al., Chemical Abstracts, vol. 104, p. 26, AB#61594J, (1986).
D. L. Romero, et al., Proc. Natl. Acad. Sci. USA, vol. 88, pp. 8806-8810, (Oct. 1991).
Houlihan et al, Indole (Part III), pp. 306, 309, 310, 314, 315, 461, 462, 476, 477 (1979).

Affiliated with

Also associated with

Rating

Inhibitors of HIV reverse transcriptase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of HIV reverse transcriptase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of HIV reverse transcriptase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-223234